早期的抗体治疗可以诱导长期免疫力
Yoshiaki Nishimura1, Rajeev Gautam1, Tae-Wook Chun2
1Laboratory of Molecular Microbiology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA.
在中使用广泛中和抗体 (bNAbs) 的早期被动免疫疗法导致了持久的感染控制. 这种方法确立了T细胞免疫力,与联合抗逆转录病毒疗法不同,可长期抑制猿类/人类免疫缺陷病毒 (SHIV).
科学领域:
- 免疫学
- 病毒学
- 传染性疾病
背景情况:
- 广泛中和抗体 (bNAbs) 可以暂时抑制lentivirus复制,但不能导致慢性感染模型的持久控制.
- 之前的免疫疗法研究表明,在感染动物服用bNAb后,病毒会复发并导致疾病的进展.
研究的目的:
- 研究使用bNAbs的早期被动免疫疗法对/人类免疫缺陷病毒 (SHIV) 感染的长期控制的有效性.
- 确定早期的bNAb治疗是否可以建立T细胞免疫力以长期抑制病毒.
主要方法:
- 对进行了SHIVAD8-EO的挑战,并接受了两周的强效bNAbs (3BNC117和10-1074).
- 对病毒载量,CD4+ T细胞数量和T细胞反应进行了监测.
- 与接受联合抗逆转录病毒疗法 (cART) 的进行了比较.
主要成果:
- 早期使用bNAb导致56至177天内无法检测到的病毒血症.
- 在13只接受治疗的中,有6只成为无法检测到的血病毒载荷的控制者.
- 另外四只保持了CD4+T细胞数量和低病毒血量超过2年,T细胞耗尽导致病毒反弹.
结论:
- 在急性SHIV感染期间的被动免疫治疗有助于产生强大的CD8+T细胞免疫力.
- 这种T细胞免疫导致病毒复制的持久控制,不同于cART,在中断时导致反弹病毒性.
- 早期的bNAb干预是实现长期控制隐形病毒感染的潜在策略.
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