大脑小粒细胞编码了对奖励的期望
Mark J Wagner1, Tony Hyun Kim1,2, Joan Savall1
1Department of Biology and Howard Hughes Medical Institute, Stanford University, Stanford, California 94305, USA.
Nature
|March 22, 2017
概括
大脑小粒细胞是最丰富的大脑神经元,它们编码的不仅仅是运动. 新的研究表明,这些细胞还信号奖励预期,扩大小脑在认知中的作用.
科学领域:
- 神经科学是一个神经科学.
- 大脑小叶的功能
- 认知神经科学 认知神经科学
背景情况:
- 小脑颗粒细胞是大脑中最多的神经元.
- 经典理论认为,它们主要编码感觉运动上下文.
- 关于小脑在认知中的作用的证据越来越多,但颗粒细胞的功能仍在争论中.
研究的目的:
- 为了调查小脑颗粒细胞是否编码非感官运动信息,特别是奖励期望.
- 探索颗粒细胞在超出运动控制的认知过程中的作用.
主要方法:
- 两光子成像在行为小鼠执行自愿前肢运动的奖励.
- 利用帕夫洛夫的条件化任务来评估对奖励和遗漏的反应.
- 在学习期间,在多天内跟踪单个颗粒细胞活动.
主要成果:
- 颗粒细胞对奖励交付,奖励遗漏和奖励预期表现出不同的反应.
- 在多个小脑叶中观察到与奖励相关的信号,独立于前肢运动.
- 与可预测的奖励相比,意想不到的奖励引起了不同的颗粒细胞活动.
- 学习动态揭示了奖励预测细胞从奖励交付响应者的出现.
结论:
- 大脑小粒细胞编码关于奖励期望的预测信息,挑战经典观点.
- 这一发现扩大了已知的颗粒细胞的功能表以及小脑在认知中的作用.
- 颗粒细胞为普尔金耶细胞提供丰富的上下文信息,影响认知处理.
相关概念视频
Diencephalon: Thalamus and Information Relay
5.1K
The thalamus, often called “the gateway to the cerebral cortex,” is vital in processing and directing sensory and motor signals throughout the brain. Almost all inputs destined for the cerebral cortex, except for olfactory signals, are relayed through the thalamus. The thalamus is a sophisticated relay station, channeling information from various brain regions to the cerebral cortex, as well as a filter, prioritizing certain signals over others based on current physiological...
5.1K
Major Somatic Sensory Pathways
3.2K
Sensory impulses related to touch, pressure, vibration, and proprioception from various body parts, such as the limbs, trunk, neck, and posterior head, travel to the cerebral cortex through the posterior column-medial lemniscus pathway. The pathway’s name derives from the two white-matter tracts that convey the impulses: the spinal cord's posterior column and the brainstem's medial lemniscus. First-order sensory neurons extend their axons into the spinal cord, forming the...
3.2K
Cerebellum: Anatomical Regions
5.2K
The cerebellum, also known as the "little brain," is located in the posterior cranial fossa, inferior to the tentorium cerebelli and dorsal to the brainstem. It plays a significant role in motor control, coordination, and proprioception.
Cerebellar Structure
Externally, the cerebellum features a highly convoluted surface with numerous folia (narrow ridges) separated by shallow sulci (grooves). The cerebellum is divided into two hemispheres by a thin median structure known as the vermis. The...
Cerebellar Structure
Externally, the cerebellum features a highly convoluted surface with numerous folia (narrow ridges) separated by shallow sulci (grooves). The cerebellum is divided into two hemispheres by a thin median structure known as the vermis. The...
5.2K
Graded Potential
7.8K
Graded potentials are localized fluctuations in the cell membrane's electrical charge, commonly found in the dendrites of neurons. The magnitude of these potential changes depends on the strength of the initiating stimulus. In a membrane at its resting potential, a graded potential signifies a voltage shift either above -70 mV or below -70 mV.
Graded potentials fall into two categories: depolarizing and hyperpolarizing. Depolarizing graded potentials typically occur when sodium (Na+) or...
Graded potentials fall into two categories: depolarizing and hyperpolarizing. Depolarizing graded potentials typically occur when sodium (Na+) or...
7.8K
Functions of the Nervous System
8.1K
The nervous system is responsible for coordinating and regulating the body's functions. It functions through three main processes: sensory, integrative, and motor processes. Sensory function involves the detection and transmission of information about internal and external stimuli from sensory receptors to the CNS. The CNS processes this information through an integrative function, where it interprets and makes decisions based on the incoming sensory information. Finally, the motor function...
8.1K
The Role of Ion Channels in Neuronal Computation
4.0K
A postsynaptic neuron usually receives numerous impulses from several other presynaptic neurons. The axon hillock of the postsynaptic neuron integrates all these signals and determines the likelihood of firing an action potential.
Sometimes a single EPSP is strong enough to induce an action potential in the postsynaptic neuron. However, multiple presynaptic inputs must often create EPSPs around the same time for the postsynaptic neuron to be sufficiently depolarized to fire an action potential....
Sometimes a single EPSP is strong enough to induce an action potential in the postsynaptic neuron. However, multiple presynaptic inputs must often create EPSPs around the same time for the postsynaptic neuron to be sufficiently depolarized to fire an action potential....
4.0K


