有效的结合免疫疗法用于抵抗割的前列腺癌
Xin Lu1, James W Horner2, Erin Paul2
1Department of Cancer Biology, The University of Texas MD Anderson Cancer Center, Houston, Texas 77030, USA.
Nature
|March 22, 2017
概括
结合免疫检查点阻塞与骨髓衍生抑制细胞向治疗,有望治疗转移性抵抗割的前列腺癌 (mCRPC). 这种新的方法克服了抗药性并增强了mCRPC的抗瘤反应.
科学领域:
- 癌症学
- 免疫学
- 癌症治疗
背景情况:
- 转移性抵抗割的前列腺癌 (mCRPC) 往往会在抗雄激素治疗中进展.
- 免疫检查点阻塞 (ICB) 在各种癌症中表现出有效性,但在mCRPC中面临抵抗.
- 骨髓衍生抑制细胞 (MDSC) 有助于瘤免疫逃避和前列腺癌的进展.
研究的目的:
- 在mCRPC中研究ICB与MDSC向治疗的有效性.
- 在本土环境中开发一种新奇的模拟小鼠模型来测试组合疗法.
主要方法:
- 开发了一种新的mCRPC仿真小鼠模型.
- 经过测试的抗CTLA4和抗PD1 (ICB) 与MDSC向药物的联合治疗 (cabozantinib,BEZ235).
- 评估了抗瘤活性,并阐明了潜在机制.
主要成果:
- 结合ICB和MDSC向治疗在mCRPC中显示出强大的协同抗瘤反应.
- 使用ICB或MDSC向药物的单一治疗显示出极少的疗效.
- 联合治疗导致了互白素-1受体抗剂的上调和抑制MDSC促进细胞因子.
结论:
- 结合ICB与MDSC向治疗,为克服耐药性和提高mCRPC治疗效率提供了一个有希望的策略.
- 这种方法需要对mCRPC治疗进行进一步的临床研究.
更多相关视频
11:02Induction of Invasive Transitional Cell Bladder Carcinoma in Immune Intact Human MUC1 Transgenic Mice: A Model for Immunotherapy Development
Published on: October 30, 2013
21.8K
12:13Sequencing Small Non-coding RNA from Formalin-fixed Tissues and Serum-derived Exosomes from Castration-resistant Prostate Cancer Patients
Published on: November 19, 2019
7.3K
相关概念视频
01:27Tumor Immunotherapy
2.1K
Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
2.1K
01:30Cancer Vaccines
1.2K
Cancer treatment vaccines are a rapidly evolving field that offers a promising approach to immunotherapy. Unlike traditional vaccines that prevent diseases, cancer treatment vaccines are designed to treat existing cancers by stimulating the immune system to recognize and attack cancer cells.
Cancer vaccines come in two categories: preventive (prophylactic) and treatment (active). Preventive vaccines, such as the Human Papillomavirus (HPV) vaccine, protect against viruses that cause certain...
Cancer vaccines come in two categories: preventive (prophylactic) and treatment (active). Preventive vaccines, such as the Human Papillomavirus (HPV) vaccine, protect against viruses that cause certain...
1.2K
02:50Combination Therapies and Personalized Medicine
6.3K
Combining two or more treatment methods increases the life span of cancer patients while reducing damage to vital organs or tissue from the overuse of a single treatment. Combination therapy also targets different cancer-inducing pathways, thus reducing the chances of developing resistance to treatment.
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
6.3K