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溶解体胆固醇通过SLC38A9-尼曼-皮克C1信号复合体激活mTORC1

Brian M Castellano1,2, Ashley M Thelen1,2, Ofer Moldavski1,2

  • 1Department of Molecular and Cell Biology, University of California at Berkeley, Berkeley, CA 94720, USA.

Science (New York, N.Y.)
|March 25, 2017
PubMed
概括

胆固醇是一种关键的生长营养素,激活了溶解体中的拉巴胺复合体1 (mTORC1) 的机械性点. 这一过程涉及SLC38A9-NPC1复合体,将溶酶体胆固醇与细胞生长信号联系起来.

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