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美国预防服务工作组的查:证据报告和系统审查

Roger Chou¹, Christina Bougatsos², Ian Blazina²

¹The Pacific Northwest Evidence-based Practice Center, Departments of Medicine and Medical Informatics and Clinical Epidemiology, Oregon Health & Science University, Portland.

|March 29, 2017

概括

在无症状个体中查胰腺疾病显示出像IgA组织转质胺酶这样的诊断测试的高准确性. 然而,对查本身的益处和危害的证据有限,需要进一步研究.

科学领域:

胃肠病学
预防医学
诊断的准确性

背景情况:

静态或亚临床腹腔疾病可能导致可预防的不良健康结果.
查的目的是识别可能受益于早期干预的个体.

研究的目的:

审查无症状人群中查的益处和危害的证据.
评估血清学检测的诊断准确性.

主要方法:

随机临床试验,队列研究和病例对照研究的系统审查.
搜索了Ovid MEDLINE,可克伦控制试验中心注册表和可克伦系统审查数据库.
独立调查人员进行数据提取和质量评估.

主要成果:

在诊断腹腔疾病时,IgA组织转质胺酶测试的高准确性 (灵敏度和特异性> 90%).
在无症状患者群体中报告的血清检测敏感度较低 (57% - 71%).
关于查益处的证据有限;一个小型试验显示无质饮食对胃肠道症状的改善很小.

结论:

对于腹腔疾病的诊断测试显示出高准确性.
关于查无症状个体的益处和危害的证据不足.
进一步的研究对于确定最佳查策略和治疗效果至关重要.

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