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Updated: May 12, 2026

Isolation of Region-specific Microglia from One Adult Mouse Brain Hemisphere for Deep Single-cell RNA Sequencing
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Published on: December 3, 2019

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通过单细胞RNA-seq在IDH突变质瘤中的遗传学,血统和微环境的脱

Andrew S Venteicher1,2,3, Itay Tirosh4, Christine Hebert1,2

  • 1Department of Pathology and Center for Cancer Research, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA.

Science (New York, N.Y.)
|April 1, 2017
PubMed
概括

这项研究表明,IDH突变星细胞瘤和寡质瘤之间的差异主要来自瘤微环境 (TME) 和遗传事件. 瘤等级会影响TME内的细胞增殖,未分化细胞和巨细胞活动.

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相关概念视频

RNA-seq03:21

RNA-seq

RNA sequencing, or RNA-Seq, is a high-throughput sequencing technology used to study the transcriptome of a cell. Transcriptomics helps to interpret the functional elements of a genome and identify the molecular constituents of an organism. Additionally, it also helps in understanding the development of an organism and the occurrence of diseases. 
Before the discovery of RNA-seq, microarray-based methods and Sanger sequencing were used for transcriptome analysis. However, while microarray-based...