美国甲状腺癌发病率和死亡率的趋势,1974-2013年
Hyeyeun Lim1, Susan S Devesa2, Julie A Sosa3
1Radiation Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland.
JAMA
|April 1, 2017
概括
美国的甲状腺癌发病率显著上升,尤其是乳头甲状腺癌. 虽然总体死亡率仍然很低,但晚期乳头甲状腺癌的死亡率呈上升趋势.
科学领域:
- 癌症学
- 流行病学
- 公共卫生
背景情况:
- 在过去的40年里, 美国甲状腺癌的发病率大幅增加.
- 这种增长主要归因于乳头甲状腺癌诊断的激增.
- 增加的乳头甲状腺癌发病率与死亡率趋势之间的关系尚不清楚.
研究的目的:
- 研究和比较甲状腺癌发病率和死亡率的趋势.
- 根据诊断时的特定瘤特征分析这些趋势.
- 评估乳头甲状腺癌率与死亡率之间的相关性.
主要方法:
- 使用了来自监测,流行病学和最终结果-9 (SEER-9) 癌症注册程序的数据.
- 1974年至2013年年龄调整后甲状腺癌发病率和发病率死亡率的评估趋势
- 使用日志线性回归来计算按组织学类型和SEER阶段的年率百分比变化.
主要成果:
- 从1974年到2013年,甲状腺癌的发病率平均每年增加3.6%,主要由乳头甲状腺癌驱动 (每年增加4.4%).
- 乳头甲状腺癌发病率在所有SEER阶段都上升,包括局部 (4.6%),区域 (4.3%) 和远程 (2.4%).
- 基于发病率的死亡率每年总体上升1.1% (1994-2013),远期乳头甲状腺癌的年增幅为2.9%.
结论:
- 在1974年至2013年期间,美国甲状腺癌的总发病率每年增加约3%.
- 观察到晚期乳头甲状腺癌的发病率和死亡率同时上升.
- 这些发现表明美国甲状腺癌的发病率确实有所增加.
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