从肝细胞癌中发现了一种新的视网膜酸受体
D Benbrook1, E Lernhardt, M Pfahl
1Cancer Research Center, La Jolla Cancer Research Foundation, California 92037.
Nature
|June 16, 1988
概括
科学家们发现了一种新的视网膜酸受体,对于生长和视力等维生素A功能至关重要. 这种受体在上皮组织中高度表达,其基因在肝癌中被发现,这表明它在瘤发育中的作用.
科学领域:
- 分子生物学分子生物学
- 内分泌学 在内分泌学.
- 细胞生物学 细胞生物学
背景情况:
- 维生素A (视网醇) 和其代谢物 (视网) 对包括生长,视力和生殖在内的关键生理过程至关重要.
- 视网类药物作用背后的精确分子机制在很大程度上仍未被定义.
- 最近确定了一种特定的核受体,用于关键的视网酸,视网,属于类固醇/甲状腺激素受体超级家族.
研究的目的:
- 识别和描述类固醇/甲状腺激素受体家族中的新型细胞内受体.
- 研究新发现的视网膜酸受体的功能和表达模式.
主要方法:
- 使用来自人类胎盘图书馆的补充DNA克隆对未表征的细胞内受体进行分析.
- 基因表达分析以确定组织分布.
- 在肝细胞癌样本中识别受体基因.
主要成果:
- 发现了第二个视网酸受体.
- 这种新型受体在各种上皮组织中高度表达.
- 这种受体的基因被确定在肝细胞癌中,与乙型肝炎病毒集成部位相邻.
结论:
- 已经确定了第二种视网膜酸受体,扩大了我们对视网膜酸信号通路的理解.
- 该受体在上皮组织中的高表达表明它在这些细胞类型中起着重要作用.
- 受体基因与乙型肝炎病毒在肝癌中集成的关联表明它可能在肝癌发生过程中起作用.
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