相关实验视频

Updated: May 3, 2026

Quantitative Analysis and Characterization of Atherosclerotic Lesions in the Murine Aortic Sinus
06:43

Quantitative Analysis and Characterization of Atherosclerotic Lesions in the Murine Aortic Sinus

Published on: December 8, 2013

14.0K

P2X7 缺陷阻断损伤性炎症体活动并改善小鼠的动脉样硬化

Peter Stachon1, Adrian Heidenreich2, Julian Merz2

  • 1From Department of Cardiology and Angiology I, Heart Center Freiburg University, Germany (P.S., A.H., J.M., I.H., D.W., F.W., S.v.G., P.A., C.H., N.H., J.R., C.v.z.M., C.B., A.Z.); and Faculty of Medicine (P.S., A.H., J.M., I.H., D.W., F.W., S.v.G., P.A., C.H., N.H., J.R., C.v.z.M., C.B., M.I., A.Z.) and Faculty of Biology (J.M.) and Department of Pneumology (N.E., M.I.), University of Freiburg, Germany. peter.stachon@universitaets-herzzentrum.de.

Circulation
|April 6, 2017
PubMed
概括

纯能受体P2X7 (P2X7) 轴在炎症酶激活和动脉样硬化中起着关键作用. 阻断P2X7信号减少了斑块炎症和实验性动脉样硬化,这表明P2X7是潜在的治疗点.

关键词:
P2X7 其他动脉样硬化炎症组炎症的发生巨细胞

更多相关视频

A Rat Carotid Balloon Injury Model to Test Anti-vascular Remodeling Therapeutics08:42

A Rat Carotid Balloon Injury Model to Test Anti-vascular Remodeling Therapeutics

Published on: September 19, 2016

8.3K
Induction of Atherosclerotic Plaques Through Activation of Mineralocorticoid Receptors in Apolipoprotein E-deficient Mice07:36

Induction of Atherosclerotic Plaques Through Activation of Mineralocorticoid Receptors in Apolipoprotein E-deficient Mice

Published on: September 26, 2018

9.7K

相关概念视频

Inflammation01:38

Inflammation

Overview
46.6K
Coronary Artery Disease II: Pathophysiology01:26

Coronary Artery Disease II: Pathophysiology

Coronary Artery Disease (CAD) originates from a series of events that impair the function of coronary arteries, the blood vessels responsible for delivering oxygen-rich blood to the heart muscle. The pathophysiology of CAD is closely linked to atherosclerosis, a chronic inflammatory and lipid-driven condition affecting the vascular endothelium.1. Endothelial DamageThe process begins with damage to the vascular endothelium, which serves as a protective barrier between the blood and the vessel...
1.1K
Atherosclerosis I: Introduction01:30

Atherosclerosis I: Introduction

Atherosclerosis is a progressive disorder characterized by the buildup of plaques on the arterial inner wall, causing them to narrow and harden over time. These plaques comprise lipids, calcium, blood components, carbohydrates, and fibrous tissue. The process primarily affects the intima of large and medium-sized arteries, reducing blood flow in any artery.Etiology and risk factorsThe cause of atherosclerosis is multifactorial, involving a complex interplay among endothelial injury, lipid...
2.5K
Atherosclerosis III: Management01:26

Atherosclerosis III: Management

Management of atherosclerosis involves an integrated strategy encompassing pharmacological treatment, surgical interventions, lifestyle changes, and nutrition therapy to address the multifactorial nature of the disease.Pharmacological TherapyA cornerstone of atherosclerosis management is the use of pharmacological agents. Statins, such as atorvastatin, are pivotal in inhibiting HMG-CoA reductase, an enzyme that catalyzes an initial step in cholesterol synthesis in the liver. This reduction in...
741
Peripheral Artery Disease I: Introduction01:30

Peripheral Artery Disease I: Introduction

Peripheral artery disease (PAD) predominantly results from atherosclerosis, which involves the accumulation of fatty deposits, or plaques, within the walls of arteries. This causes them to narrow and harden, significantly reducing blood flow. PAD predominantly affects the legs, particularly the arteries supplying the thighs and calves. In rare cases, it may involve other arteries, including those in the arms.Etiology of PAD:The principal cause of PAD is atherosclerosis, which results from fatty...
659