卫星DNA序列与D. melanogaster中分离扰乱器的响应器之间的关联
1Department of Biology, University of Rochester, New York 14627.
Cell
|July 15, 1988
概括
卫星DNA重复被假设是D. melanogaster中的响应器 (Rsp) 元素,导致精子功能障碍和介质驱动. 这个重复数组数组.
科学领域:
- 遗传学 是一个遗传学.
- 分子生物学分子生物学
- 进化生物学 进化生物学
背景情况:
- 在Drosophila melanogaster中,分离干扰器 (SD) 遗传系统会影响介质驱动.
- 响应器 (Rsp) 元素是SD的关键组成部分,与卫星DNA序列相关.
- 在精子生成过程中,RSP会导致异常的染色质凝结,导致RSP携带精子的传播减少.
研究的目的:
- 为了研究响应器 (Rsp) 元素的分子同一性.
- 确定相关卫星DNA序列在RSP功能和介质驱动中的作用.
- 了解RSP位置的结构动态和进化可塑性.
主要方法:
- 对与Rsp.相关的卫星DNA阵列的分析.
- 对 Y 染色体的 Rsp 缺失和转位的检查.
- 重复拷贝数与介质驱动器灵敏度的相关性.
主要成果:
- 一大批卫星DNA序列始终与Rsp元素一起发现.
- 卫星重复阵列被删除或与RSP一起转移.
- 卫星重复的数量与对介质驱动的敏感性有很强的相关性.
结论:
- 建议卫星DNA重复阵列构成功能响应器 (Rsp) 元素.
- 位点的变异性和结构动态表明活跃的分子进化.
- 了解RSP位置,可以了解介质驱动和重复性DNA元素的演变.
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