一个由皮肤制成的活体细胞自动机
Liana Manukyan1,2, Sophie A Montandon1, Anamarija Fofonjka1,2
1Laboratory of Artificial and Natural Evolution (LANE), Department of Genetics and Evolution, University of Geneva, Geneva, Switzerland.
Nature
|April 14, 2017
概括
而不是单个细胞, 而是由细胞自动机产生的迷宫般的皮肤图案. 这种生物过程源于图灵反应扩散系统,
科学领域:
- 发育生物学
- 数学生物学
- 埃沃 - 德沃
背景情况:
- 脊椎动物的皮肤颜色是由复杂的细胞相互作用引起的.
- 之前的模型集中在单个染色体细胞上.
研究的目的:
- 调查的迷宫性皮肤颜色模式背后的机制.
- 为了确定皮肤,而不是染色体,驱动模式的形成.
- 将生物模式生成与细胞自动机等计算模型联系起来.
主要方法:
- 分析四年时间序列的尺度颜色动态.
- 基于规模交互的细胞自动机模型的开发.
- 数字模拟和数学导出连接图灵反应扩散系统到细胞自动机.
主要成果:
- 而不是单个细胞, 决定了绿色和黑色的迷宫图案.
- 一个细胞自动机模型准确计算尺度颜色状态,产生宏观图案.
- 皮肤厚度的变化是由于尺度形态生成而分离空间尺度,使细胞自动机从反应-扩散动态中出现.
结论:
- 细胞自动机可以直接代表生物进化的模式形成过程.
- 这项研究揭示了在生物环境中连续反应扩散系统和离散细胞自动机之间的新联系.
- 基于尺度的计算为了解脊椎动物皮肤模式提供了一个新的框架.
相关概念视频
Renewal of Skin Epidermal Stem Cells
3.0K
The skin is divided into epidermis, dermis, and hypodermis, the skin's outermost, middle, and inner layers. The human epidermal layer regularly undergoes renewal, where old, dead cells are replaced by new cells. Epidermal stem cells or EpiSCs divide and differentiate to restore the lost cells. For the renewal process, some EpiSCs continuously self-renew. In contrast, few others differentiate into transit-amplifying cells, which later form prickle or spinous cells, followed by granular...
3.0K
Cell Diversity
4.7K
The concept of a cell started with microscopic observations of dead cork tissue by Robert Hooke in 1665. Hooke coined the term "cell" based on the resemblance of the small subdivisions in the cork to the rooms that monks inhabited, called cells. About ten years later, Antonie van Leeuwenhoek became the first person to observe the living and moving cells under a microscope. In the century that followed, the theory that cells represented the basic unit of life developed.
Multicellular...
Multicellular...
4.7K


