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通过转子插入进行线性放大单细胞全基因组分析 (LIANTI)

Chongyi Chen1, Dong Xing1, Longzhi Tan1

  • 1Department of Chemistry and Chemical Biology, Harvard University, Cambridge, MA 02138, USA.

Science (New York, N.Y.)
|April 15, 2017
PubMed
概括

一种新的方法,通过转子插入进行线性放大 (LIANTI),通过改进拷贝数变异检测和揭示DNA复制起源来增强单细胞基因组学. 它还阐明了单细胞研究中的突变工件.

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As the name suggests, non-LTR retrotransposons lack the long terminal repeats characteristic of the LTR retrotransposons. Additionally, both LTR and non-LTR retrotransposons use distinct mechanisms of mobilization. Non-LTR retrotransposons are further divided into two classes - Long interspersed nuclear elements (LINEs) and short interspersed nuclear elements (SINEs), both of which occur abundantly in most mammals, including humans. Some of the active non-LTR retrotransposons in humans are L1...
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