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相关概念视频

Design Consideration01:22

Design Consideration

681
Designing a structure involves a series of considerations, primarily the material's ultimate strength, calculated through tests that measure changes under increased force until the material reaches its breaking point or limit. The ultimate load, where the material breaks, is divided by its original cross-sectional area, resulting in the ultimate normal stress or strength. The ultimate shearing stress is another significant factor taken into account.
The factor of safety is another key...
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Plastic Behavior01:21

Plastic Behavior

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A material's elastic behavior is characterized by the disappearance of stress once the load is removed, allowing the material to return to its original state. However, when stress surpasses the yield point, yielding commences, marking the onset of plastic deformation or permanent set. This change from elastic to plastic behavior is influenced by the peak stress value and the duration before the load is removed. An intriguing observation occurs when a specimen is loaded, unloaded, and...
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Fatigue01:21

Fatigue

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Fatigue occurs when materials rupture under repeated or fluctuating loads, even at stress levels far below their static breaking strength. It typically results in brittle failure, even for ductile materials. It is a critical consideration in designing machines and structural components subjected to repetitive or varying loads. The nature of these loadings can range from fluctuating loads like unbalanced pump impellers causing vibrations to repeatedly bending a thin steel rod wire back and forth...
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Bulk Modulus01:21

Bulk Modulus

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The bulk modulus is a scientific term used to describe a material's resistance to uniform compression. It is the proportionality constant that links a change in pressure to the resulting relative volume change.
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Toughness and Hardness of Aggregate01:22

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Toughness and hardness are critical properties of aggregate materials used in concrete, particularly on pavement surfaces and industrial flooring subjected to heavy loads. Toughness is defined as the aggregate's resistance to failure by impact and is measured by the aggregate impact value (AIV). For this, the aggregate impact value test is performed, wherein the impact is delivered by a standard hammer, which falls freely under its own weight onto the aggregates. The aggregates fragment in...
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Optimization Problems01:26

Optimization Problems

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Optimization problems often involve identifying maximum or minimum values under specific constraints. A well-known example is determining the longest horizontal pipe that can be moved around a right-angled corner, where a 3-meter-wide hallway meets a 2-meter-wide hallway. This scenario, common in architectural design and industrial transport, can be understood conceptually through geometric and trigonometric reasoning.To visualize the problem, consider the pipe as a straight line that touches...
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Quantitative Hardness Measurement by Instrumented AFM-indentation
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系统性硬化

Christopher P Denton1, Dinesh Khanna2

  • 1UCL Division of Medicine, University College London, London, UK; UCL Centre for Rheumatology and Connective Tissue Diseases, Royal Free Hospital, London, UK.

Lancet (London, England)
|April 18, 2017
PubMed
概括
此摘要是机器生成的。

系统性硬化 (硬皮症) 是一种严重的自身免疫性疾病,导致纤维化. 进展改善了并发症的管理和治疗,但非致命症状仍然是一个重大挑战.

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科学领域:

  • 关节病学
  • 免疫学
  • 纤维化研究

背景情况:

  • 系统性硬化症 (硬性皮质症) 是一种由纤维化和血管疾病为特征的免疫媒介性风湿性疾病.
  • 它具有显著的发病率和死亡率,影响皮肤和内部器官.
  • 最近的进展改善了理解,分类和管理策略.

研究的目的:

  • 审查系统性硬化症的临床特征.
  • 描述疾病管理的最佳实践方法.
  • 确定未来的研究和开发领域.

主要方法:

  • 对临床特征和治疗策略的文献审查.
  • 对治疗方法的现有证据的综合.
  • 分析疾病负担和未来的挑战.

主要成果:

  • 改进的分类和系统评估有助于改善疾病管理.
  • 新兴的治疗方法,包括免疫抑制,对皮肤和肺纤维化有效.
  • 现在可以治疗危机和肺高血压等特殊并发症.

结论:

  • 虽然特定并发症的管理和治疗已取得进展,但非致命性全身性硬化症并发症的负担需要进一步关注.
  • 最佳实践管理包括系统评估和有针对性的治疗.
  • 未来的研究应该集中在解决非致命症状的重大负担上.