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The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
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超分子光活性抗癌水凝

V Venkatesh1, Narendra Kumar Mishra2, Isolda Romero-Canelón1

  • 1Department of Chemistry, University of Warwick , Gibbet Hill Road, Coventry CV4 7AL, United Kingdom.

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新的 (IV) 抗癌药物结合物 (Pt-DA) 被嵌入到G-四重体水凝中. 由此产生的 Pt-G4K+B 水凝对卵巢癌细胞具有增强的光细胞毒性.

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科学领域:

  • 生物医学工程
  • 材料科学
  • 癌症学

背景情况:

  • (IV) 复合物在癌症治疗中具有潜力.
  • 在药物输送方面探索G-四重体结构和水凝.
  • 可光激活药物可以增强向癌症治疗.

研究的目的:

  • 开发一种可光激活的 (IV) 抗癌复合物,
  • 研究新型水凝系统的光细胞毒性和选择性.

主要方法:

  • 一种可光激活多巴胺合 (Pt-DA) 复合物的合成和表征.
  • 通过玻酸链接将Pt-DA纳入G-四重体G4K+玻酸 (Pt-G4K+B) 中.
  • 使用蓝光照射对抗抗西斯普拉丁的卵巢癌细胞和正常纤维细胞的光细胞毒性评估.

主要成果:

  • 显微镜证实了Pt-DA加入后水凝的结构变化.
  • 对于A2780Cis细胞 (IC50 74 μM) Pt- DA具有光细胞毒性.
  • Pt- G4K+B水凝显著增强光细胞毒性 (IC50为3μM),具有较高的光细胞毒性指数 (> 5).
  • 无论是Pt- DA还是Pt- G4K+B,都对癌细胞具有选择性毒性,而不是正常的纤维细胞.

结论:

  • 开发的Pt-G4K+B水凝是针对性光化疗的一个有前途的平台.
  • 水凝配方增强了可光激活复合物的功效和选择性.
  • 这种方法有望改善对西斯普拉丁耐药性卵巢癌的治疗.