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Updated: May 10, 2026

Preparation of Acute Hippocampal Slices from Rats and Transgenic Mice for the Study of Synaptic Alterations during Aging and Amyloid Pathology
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人类带血蛋白恢复老鼠海马功能

Joseph M Castellano1,2, Kira I Mosher1,2,3, Rachelle J Abbey1,2,4

  • 1Department of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, California 94305, USA.

Nature
|April 21, 2017
PubMed
概括

人类带血能恢复老化的海马体并增强小鼠的认知功能. 带血中的金属蛋白酶2 (TIMP2) 组织抑制剂是促进可塑性的关键.

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In the CNS, neurogenesis, the birth of new neurons from stem cells, is limited to the hippocampus in adults. In other regions of the brain and spinal cord, neurogenesis is almost non-existent due to inhibitory influences from neuroglia, especially oligodendrocytes, and the absence of growth-stimulating cues. The myelin produced by oligodendrocytes in the CNS inhibits neuronal regeneration. Furthermore, astrocytes proliferate rapidly after neuronal damage, forming scar tissue that physically...