一夫一妻制小鼠的家长照顾演变的遗传基础
Andres Bendesky1,2,3, Young-Mi Kwon1,2, Jean-Marc Lassance1,2,3
1Howard Hughes Medical Institute, Harvard University, Cambridge, Massachusetts 02138, USA.
Nature
|April 21, 2017
概括
在小鼠的家长关怀中存在差异是遗传的,并且与特定的基因有关. 发现一种神经, 影响了巢建行为, 提供了父母关怀的进化.
科学领域:
- 进化生物学
- 行为遗传学
- 神经内分泌学
背景情况:
- 父母的照顾对于哺乳动物的生存至关重要,但其进化驱动因素尚未得到充分理解.
- 在密切相关的小鼠物种Peromyscus polionotus和Peromyscus maniculatus之间存在显著的遗传行为差异.
研究的目的:
- 调查父母关怀的跨物种差异的遗传基础.
- 识别影响不同父母行为的特定基因和神经,例如筑巢.
主要方法:
- 量化遗传学被用来绘制与父母关怀相关的基因组区域.
- 用药理学和化学遗传技术测试了压素在Peromyscus和Mus小鼠的亲子行为中的作用.
主要成果:
- 确定了12个影响家长护理的基因组区域,其中8个显示性别特异性影响.
- 下丘脑中的血管压素水平与筑行为减少有关.
- 证实压素能特别抑制的形成,而不是其他父母的照顾行为.
结论:
- 基因变异,包括神经压素,有助于各种父母护理策略的演变.
- 由于性别特异性的遗传影响,父母的照顾在男性和女性中可以独立发展.
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