新生儿获得克洛斯特里迪亚物种可以防止细菌病原体的殖民
Yun-Gi Kim1,2, Kei Sakamoto3,2, Sang-Uk Seo3,2
1Department of Pathology, University of Michigan Medical School, Ann Arbor, MI 48109, USA. gabriel.nunez@umich.edu yungikim77@gmail.com.
Science (New York, N.Y.)
|April 22, 2017
概括
新生小鼠缺乏对病原体的肠道微生物保护,这是由于缺少Clostridiales. 补充Clostridiales可以恢复殖民抵抗力,强调其在婴儿免疫力中的关键作用.
科学领域:
- 微生物学
- 免疫学
- 胃肠病学
背景情况:
- 新生儿易受感染, 常常是由于免疫系统不成熟.
- 这种脆弱性背后的确切机制以及肠道微生物群的作用仍然不完全理解.
研究的目的:
- 研究肠道微生物组合在新生儿对细菌病原体的抗殖性中的作用.
- 确定负责生命早期保护的特定细菌种群.
主要方法:
- 用新生儿和成年小鼠菌菌群对成年无菌小鼠进行殖民.
- 挑战殖民小鼠使用已知导致新生儿死亡的特定细菌病原体.
- 使用特定的细菌类 (Clostridiales, Bacteroidales) 来评估保护作用.
- 在成年小鼠中消耗Clostridiales以评估其对殖民抵抗的必要性.
主要成果:
- 新生儿微生物群无法阻止病原体的殖民化,与成年微生物群不同.
- 新生儿微生物群中Clostridiales的缺失与缺乏殖民抵抗有关.
- 使用Clostridiales,但不使用Bacteroidales,保护新生小鼠免受感染并减少肠道病理.
- 成年小鼠中Clostridiales的消耗消除了它们的殖民抵抗力.
- 新生儿的肠道细菌促进了保护性Clostridiales的殖民化.
结论:
- 肠道微生物群在新生儿的殖民抵抗中起着至关重要的作用, 独立于免疫系统的成熟.
- 在新生儿和成年小鼠中建立殖民抵抗力是必不可少的.
- 向使用Clostridiales可能是预防或治疗新生儿感染的治疗策略.
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