在C的环境信息跨代传输. 优雅的
Adam Klosin1,2, Eduard Casas3, Cristina Hidalgo-Carcedo1,2
1EMBL-CRG Systems Biology Unit, Centre for Genomic Regulation (CRG), European Molecular Biology Organization, 08003 Barcelona, Spain.
概括
环境变化可以改变 Caenorhabditis elegans 线虫的基因表达. 温度变化导致基因表达的遗传变化持续超过14代, 证明了表观遗传记忆.
科学领域:
- 表观遗传学
- 发育生物学
- 遗传学
背景情况:
- 环境因素可以影响后代的基因表达.
- 线虫Caenorhabditis elegans作为研究跨代遗传的模型生物.
研究的目的:
- 研究Caenorhabditis elegans中环境诱导的表观遗传变化的持续时间和机制.
- 确定温度诱导的基因表达变化是否可以在多代人中继承.
主要方法:
- 使用了Caenorhabditis elegans作为一个模型生物.
- 使用温度变化诱导基因表达的变化.
- 分析基因表达模式和基因素修饰 (H3K9me3).
- 在至少14代的表达变化中追踪遗传.
主要成果:
- 异色基因阵列表达的温度诱导变化持续至少14代.
- 通过卵细胞和精子发生遗传.
- 在胚胎转录之前观察到改变的素H3 lysine 9三甲基化 (H3K9me3).
- 表达特征分析证实了内源性抑制重复产生的遗传温度诱导表达.
结论:
- 在Caenorhabditis elegans中,环境变化的长期表观遗传记忆是可能的.
- 环境诱导的基因表达的跨代遗传是由表观遗传机制介导的.
- 基因组基因激活之前,基因组基因的修饰在建立这种表观遗传记忆中起作用.
相关概念视频
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