宿主-微生物共同代谢决定了C. elegans的癌症药物有效性
Timothy A Scott1, Leonor M Quintaneiro2, Povilas Norvaisas3
1Institute of Structural and Molecular Biology, University College London and Birkbeck, London WC1E 6BT, UK.
Cell
|April 22, 2017
概括
肠道微生物通过改变 pyrimidine 的代谢,显著影响结肠直肠癌药物的疗效. 了解这些宿主-微生物-药物相互作用可以带来个性化治疗和改善患者的结果.
科学领域:
- 微生物学
- 遗传学
- 药理学
背景情况:
- 皮里米丁是标准的结直肠癌治疗方法.
- 患者对皮里米丁的反应有显著差异.
- 肠道微生物群是个体间变化的关键因素.
研究的目的:
- 研究肠道微生物对皮里米丁疗效的影响.
- 阐明宿主-微生物-药物相互作用的机制.
- 探索药物代谢的微生物调节.
主要方法:
- 使用的遗传模型:大肠杆菌和杆菌.
- 进行了三向高通量选.
- 分析了皮里米丁的细菌代谢和宿主细胞反应.
主要成果:
- 微生物可以通过代谢相互转换来增强或减少胺的作用.
- 其中包括细菌维生素B6,B9和核糖核酸代谢.
- 受到破坏的细菌脱氧核酸池通过ndk-1增强了5-fluorouracil (5-FU) 引起的宿主细胞死亡.
结论:
- 肠道微生物群通过宿主代谢调解胺的有效性.
- 微生物操纵为结直肠癌提供了潜在的治疗策略.
- 针对肠道微生物群可以改善宿主代谢健康和疾病治疗.
更多相关视频
07:19Compost Microcosms as Microbially Diverse, Natural-like Environments for Microbiome Research in Caenorhabditis elegans
Published on: September 13, 2022
2.8K
08:38Application of Flow Vermimetry for Quantification and Analysis of the Caenorhabditis elegans Gut Microbiome
Published on: March 31, 2023
1.2K
相关概念视频
Microbial Interactions: Cooperation
66
Microbial cooperation involves beneficial interactions in which different species work together for individual or mutual advantage. These interactions can profoundly influence ecological dynamics and evolutionary processes, and they are essential to many pathogenic and symbiotic relationships.Nematode–Bacteria CooperationA striking example is the relationship between the Gram-negative bacterium Xenorhabdus nematophila and the parasitic nematode Steinernema carpocapsae. Juvenile nematodes...
66
Microbial Interactions: Parasitism
121
Parasitism is a form of microbial interaction in which parasitic microbes exploit a host organism for nutrients and shelter, often at the host's expense. Unlike mutualistic relationships, where both organisms benefit, parasitism benefits only the parasite and harms the host.Classification of ParasitesMicrobial parasites are broadly classified based on their location relative to the host.Ectoparasites remain on the host’s surface, such as the skin or outer tissues, drawing nutrients...
121
