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多聚胺通道调节贝克林1依赖的自

Avraham Ashkenazi1, Carla F Bento1, Thomas Ricketts1

  • 1Department of Medical Genetics, Cambridge Institute for Medical Research (CIMR), University of Cambridge, Cambridge, UK.

Nature
|April 27, 2017
PubMed
概括

蛋白质中的多重胺 (polyQ) 管道扩大导致神经退行性疾病. 这项研究揭示了野生类型的polyQ通道通过稳定贝克林1来实现自,这种功能因致病的polyQ扩张而被破坏.

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