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Updated: Jul 2, 2026

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Pcdhαc2 在小鼠中需要用于轴突和血清电路组合

Weisheng V Chen1,2, Chiamaka L Nwakeze1,2, Christine A Denny3,4

  • 1Department of Biochemistry and Molecular Biophysics, Columbia University, New York, NY 10032, USA.

Science (New York, N.Y.)
|April 29, 2017
PubMed
概括

在血清蛋白神经元中删除Protocadherin alfa (Pcdhα) 基因会破坏大脑电路,导致类似抑郁症的行为. 特定的Pcdhαc2异型对于正确的轴突和电路组装至关重要.

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相关概念视频

Catenins01:23

Catenins

Catenins are characterized by multiple binding domains and dynamic structures that allow them to function as linker proteins in cell junction complexes. All catenins, except α-catenin, contain a characteristic protein sequence called the armadillo repeat and are therefore also called armadillo proteins.
Catenins in Cell Junctions
Catenins bind to cell adhesion molecules such as cadherins and link them to different cytoskeletal proteins depending on the type of cell junction. At the adherens...