在光动力疗法中克服缺氧的极限:碳酸无水素IX向方法
Hyo Sung Jung1, Jiyou Han2, Hu Shi3
1Department of Chemistry, The University of Texas at Austin , Austin, Texas 78712-1224, United States.
Journal of the American Chemical Society
|May 2, 2017
概括
这项研究引入了与乙胺结合的BODIPY光敏感剂 (AZ-BPS) 来对抗光动力癌症治疗 (PDT) 中的缺氧. 通过向过度表达碳酸酶IX (CAIX) 的瘤并抑制血管生成,AZ- BPS增强了抗癌效果.
科学领域:
- 生物医学工程
- 光动力疗法
- 癌症研究
背景情况:
- 光动力疗法 (PDT) 可以诱导缺氧,促进癌症复发并降低治疗效果.
- 低氧会激活促血管生成因子,从而促进瘤的进展.
- 在侵袭性癌症中,碳酸酶IX (CAIX) 过度表达,并与缺氧有关.
研究的目的:
- 开发一种可减轻PDT诱导低氧的新型光敏感剂.
- 为了加强癌症治疗,将PDT与抗血管生成策略结合起来.
- 有效向CAIX过度表达的癌细胞.
主要方法:
- 与乙胺 (AZ) 结合的BODIPY光敏感剂 (AZ-BPS) 的合成.
- 对CAIX过度表达的MDA- MB-231癌细胞的AZ- BPS亲和度的评估.
- 在小鼠瘤模型中对光细胞毒性的 in vitro 和 in vivo 疗效的评估.
- 通过ROS生成和CAIX倒置抑制瘤血管生成的分析.
主要成果:
- 对于CAIX过度表达的癌细胞,AZ- BPS具有特定的亲和力.
- 与非结合光敏感剂 (BPS) 相比,AZ-BPS的光细胞毒性增强.
- 在体内改善AZ- BPS的瘤生长抑制,因其抗血管生成作用.
- 在临床乳腺癌患者样本中成功评估.
结论:
- AZ-BPS有效地将PDT与抗血管生成相结合,以改善癌症治疗.
- 开发的光敏感剂对向CAIX过度表达的瘤具有前景.
- 这种双重作用的方法为克服PDT诱导的缺氧和改善治疗结果提供了潜在的策略.
更多相关视频
11:04An In-House-Built and Light-Emitting-Diode-Based Photodynamic Therapy Device for Enhancing Verteporfin Cytotoxicity in a 2D Cell Culture Model
Published on: January 13, 2023
3.8K
09:45Photodynamic Therapy with Blended Conducting Polymer/Fullerene Nanoparticle Photosensitizers
Published on: October 28, 2015
8.9K
相关概念视频
02:49Cancer Therapies
10.3K
Cancer therapies are various modes of treatment, such as surgery, radiation therapy, and chemotherapy that are administered to cancer patients.
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
10.3K
01:16Treatment for Pulmonary Arterial Hypertension: Oxygen Therapy for Respiratory Failure
687
Oxygen therapy has emerged as a significant tool in enhancing the quality of life for patients suffering from pulmonary arterial hypertension (PAH). While this therapy has principally been studied on patients with significant hypoxemia, this therapeutic approach helps prevent potential organ damage and can be administered in the comfort of one's home.
Oxygen therapy is vital in increasing and maintaining blood oxygen levels in PAH patients. As a result, it aids in reducing fatigue,...
Oxygen therapy is vital in increasing and maintaining blood oxygen levels in PAH patients. As a result, it aids in reducing fatigue,...
687