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重金属可以增强瘤免疫力

Jonathan H Chen1, Karin Pelka2, Nir Hacohen2

  • 1Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA; Center for Cancer Research, Department of Medicine, Massachusetts General Hospital, Boston, MA 02114, USA; Department of Pathology, Massachusetts General Hospital, Boston, MA 02114, USA.

Cell
|May 6, 2017
PubMed
概括

了解人类癌症的免疫格局对于有效的免疫治疗至关重要. 最近的两项研究使用质量细胞计分析肺腺癌和清细胞癌的免疫细胞.

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Every normal cell or tissue is embedded in a complex local environment called stroma, consisting of different cell types, a basal membrane, and blood vessels. As normal cells mutate and develop into cancer cells, their local environment also changes to allow cancer progression. The tumor microenvironment (TME) consists of a complex cellular matrix of stromal cells and the developing tumor. The cross-talk between cancer cells and surrounding stromal cells is critical to disrupt normal tissue...
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The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
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