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相关概念视频

Pinocytosis00:38

Pinocytosis

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Cells use energy-requiring bulk transport mechanisms to transfer large particles or large numbers of small particles into or out of the cell. The cells envelop the particles in spherical membranes called vesicles or vacuoles. Vesicles that transport material into the cell are built from the cell membrane. These vesicles encapsulate external molecules and transport them into the cell in a process called endocytosis.
Pinocytosis ("cellular drinking") is one of three main types of...
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Pinocytosis00:43

Pinocytosis

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Cells use energy-requiring bulk transport mechanisms to transfer large particles, or large amounts of small particles, into or out of the cell. The cells envelop the particles in spherical membranes called vesicles or vacuoles. Vesicles that transport material into the cell are built from the cell membrane. These vesicles encapsulate external molecules and transport them into the cell in a process called endocytosis.
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Phagocytosis00:41

Phagocytosis

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Cells pull particles inward and engulf them in spherical vesicles in an energy-requiring process called endocytosis. Phagocytosis ("cellular eating") is one of three major types of endocytosis. Cells use phagocytosis to take in large objects, such as other cells (or their debris), bacteria, and even viruses.
The objective of phagocytosis is often destruction. Cells use phagocytosis to eliminate unwelcome visitors, like pathogens (e.g., viruses and bacteria). Many immune system cells,...
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Phagocytosis00:41

Phagocytosis

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Cells pull particles inward and engulf them in spherical vesicles in an energy-requiring process called endocytosis. Phagocytosis (“cellular eating”) is one of three major types of endocytosis. Cells use phagocytosis to take in large objects—such as other cells (or their debris), bacteria, and even viruses.
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Pinching-off of Coated Vesicles01:32

Pinching-off of Coated Vesicles

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Vesicle budding is orchestrated by distinct cytosolic proteins such as adaptor proteins, coat proteins, and GTPases. To initiate vesicle budding, membrane-bending proteins containing crescent-shaped BAR domains bind to the lipid heads in the bilayer and distort the membrane to form a protein-coated vesicle bud. Adaptors proteins such as AP2 for clathrin-coated vesicles can nucleate on the deformed membrane. Finally, coat proteins such as clathrin or COPI and COPII assemble into a coat forming...
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Delivery Pathways to the Lysosome01:36

Delivery Pathways to the Lysosome

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Eukaryotic cells use different mechanisms to eliminate toxic waste obsolete and worn-out substances. Lysosomes play a pivotal role in this, and hence, these substances are carried to the lysosome from other parts of the cell and extracellular space through different pathways. The most elaborately studied pathways to the lysosome are the endocytic pathways.
Endocytosis
In endocytosis, the cell membrane takes up macromolecules and particles from the surrounding medium. Clathrin-mediated...
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相关实验视频

Updated: Nov 5, 2025

Automated Imaging and Analysis for the Quantification of Fluorescently Labeled Macropinosomes
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Automated Imaging and Analysis for the Quantification of Fluorescently Labeled Macropinosomes

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快照:巨细胞

Pedro E Marques1, Sergio Grinstein2, Spencer A Freeman1

  • 1Program in Cell Biology, Peter Gilgan Centre for Research and Learning, Hospital for Sick Children, 686 Bay Street, 19-9800, Toronto, ON M5G 0A4, Canada.

Cell
|May 6, 2017
PubMed
概括
此摘要是机器生成的。

细胞的大量液体吸收是免疫监测的关键. 这一过程也会导致感染和癌症的进展.

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Measuring the pH, Redox Chemistries, and Degradative Capacity of Macropinosomes using Dual-Fluorophore Ratiometric Microscopy
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Measuring the pH, Redox Chemistries, and Degradative Capacity of Macropinosomes using Dual-Fluorophore Ratiometric Microscopy

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Visualizing Membrane Ruffle Formation using Scanning Electron Microscopy
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相关实验视频

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Automated Imaging and Analysis for the Quantification of Fluorescently Labeled Macropinosomes
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Automated Imaging and Analysis for the Quantification of Fluorescently Labeled Macropinosomes

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Measuring the pH, Redox Chemistries, and Degradative Capacity of Macropinosomes using Dual-Fluorophore Ratiometric Microscopy
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Visualizing Membrane Ruffle Formation using Scanning Electron Microscopy
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科学领域:

  • 细胞生物学
  • 免疫学
  • 病理学

背景情况:

  • 巨细胞细胞分裂是一种细胞过程,涉及通过大型内细胞真空体大量吸收细胞外液体.
  • 这种机制在包括免疫细胞功能在内的各种生理过程中起着至关重要的作用.

研究的目的:

  • 提供宏皮诺细胞的生理作用的概述.
  • 在疾病状态中探索巨细胞瘤的病原性贡献.

主要方法:

  • 关于巨细胞瘤的文献综述
  • 在免疫监测中对巨细胞的分析.
  • 在感染和癌症中对巨细胞的研究.

主要成果:

  • 抗原呈现细胞对免疫监测至关重要.
  • 异常的巨细胞瘤与癌细胞的增殖和存活有关.
  • 病原体可以利用巨细胞瘤来促进感染.

结论:

  • 巨细胞形成是一个基本的细胞过程,在健康和疾病中具有双重作用.
  • 了解巨细胞形成为感染和癌症提供了潜在的治疗点.