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GUCY1A3冠状动脉疾病风险位的功能性特征

Thorsten Kessler1, Jana Wobst2, Bernhard Wolf2

  • 1From Deutsches Herzzentrum München, Klinik für Herz-und Kreislauferkrankungen, Technische Universität München, Munich, Germany (T.K., J.W., B.W., B.V., S.V.A., T.A.D., H.B.S., P.M.R., A.K., H.S.); Sektion für Funktionelle Genetik am Institut für Humangenetik, Universität zu Lübeck, Germany (J. Eckhold, R.H., F.J.K.); Center for Public Health Genomics, Department of Biomedical Engineering, University of Virginia, Charlottesville (R.A., M.C.); DZHK e.V. (German Center for Cardiovascular Research), Partner Site Munich Heart Alliance, Munich, Germany (A.K., H.S.); Department of Genetics and Genomic Sciences, Icahn Institute for Genomics and Multiscale Biology, Icahn School of Medicine at Mount Sinai, New York, NY (J.L.M.B.); Department of Physiology, Institute of Biomedicine and Translational Medicine, University of Tartu, Estonia (J.L.M.B.); Institut für Integrative und Experimentelle Genomik and Universitäres Herzzentrum Lübeck, Universität zu Lübeck, Germany (J. Erdmann); DZHK e.V. (German Center for Cardiovascular Research), Partner Site Hamburg/Kiel/Lübeck, Lübeck, Germany (J. Erdmann, F.J.K.); and Departments of Human Genetics and Medicine, David Geffen School of Medicine, University of California, Los Angeles (A.J.L., M.C.). thorsten.kessler@tum.de schunkert@dhm.mhn.de.

Circulation
|May 11, 2017
PubMed
概括

一种常见的基因变异 (rs7692387) 通过影响GUCY1A3基因表达来影响冠状动脉疾病的风险. 转录因子ZEB1优先结合非风险等位基因,增加GUCY1A3表达并降低动脉样硬化风险.

关键词:
冠状动脉疾病遗传学全基因组关联研究基因型心肌梗塞氧化可溶性甘酸环酶

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