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由于中央视网膜静脉封闭而导致黄斑胀的患者中贝瓦西祖马布与阿弗利伯塞普对视觉敏度的影响:SCORE2随机临床试验

  • 0Department of Ophthalmology, Penn State College of Medicine, Hershey, Pennsylvania2Department of Public Health Sciences, Penn State College of Medicine, Hershey, Pennsylvania.
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2017年五月12日

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2017年五月12日

在PubMed上查看摘要

概括

此摘要是机器生成的。

在因视网膜静脉封闭而导致的黄斑胀的视力改善方面,静脉内证明与aflibercept无差别. 这一发现支持贝瓦西祖马布作为这种疾病的有效治疗选择.

科学领域

  • 眼科 眼科
  • 视网膜疾病
  • 临床试验

背景情况

  • Aflibercept 已批准用于治疗中枢视网膜静脉封闭 (CRVO) 的黄斑胀.
  • 尽管支持数据有限,但贝瓦西祖马布在CRVO治疗中被广泛使用.

研究的目的

  • 确定贝瓦西祖马布是否与阿弗利塞普特在治疗由于视网膜中心或视网膜内静脉封闭 (HRVO) 引起的黄斑胀方面具有非劣势.

主要方法

  • 在SCORE2试验中,362名CRVO/ HRVO患者被随机分组,每4周接受内置贝瓦西祖马布 (1.25 mg) 或阿弗利伯塞普 (2.0 mg) 治疗,持续6个月.
  • 主要结论是从基线到6个月的视力敏度字母得分 (VALS) 的平均变化.

主要成果

  • 在6个月后,贝瓦齐祖马布和阿弗利塞普特组的VALS平均增加约为18. 6 - 18. 9个字母.
  • 与aflibercept相比,贝瓦西祖马布达到非劣势差距 (组间差异 - 0. 14;97. 5% CI, - 3. 07至∞;P=. 001).
  • 在两组中都报告了眼部不良事件,其中一名接受贝瓦西祖马布治疗的患者患上了内炎.

结论

  • 在6个月后由于CRVO/ HRVO而导致的黄斑胀的患者中,intravitreal bevacizumab对改善视觉敏度的效果与aflibercept无差.
  • 这项研究提供了强有力的证据来支持贝瓦西祖马布在此指标的使用.

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