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从古生态起源追溯到医院的肠球菌

François Lebreton¹, Abigail L Manson², Jose T Saavedra³

¹Department of Ophthalmology and Department of Microbiology and Immunobiology, Harvard Medical School, Boston, MA 02114, USA; Department of Ophthalmology, Massachusetts Eye and Ear Infirmary, Boston, MA 02114, USA; Infectious Disease & Microbiome Program, Broad Institute, Cambridge, MA 02142, USA.

|May 16, 2017

概括

肠球菌是多种耐药性病原体,起源于425-500万年前的动物殖民. 在陆地上生存的特征解释了它们对医院的适应.

科学领域:

进化生物学
微生物学
病原体研究

背景情况:

肠球菌是医院的主要抗药性病原体.
它们对医院环境的显著适应需要进化解释.

研究的目的:

为了研究肠球菌的进化历史.
了解他们适应现代医院环境的起源.

主要方法:

分子时钟的估计.
环境分布和表型多样性的分析.
与宿主化石记录进行比较.

主要成果:

菌起源于425-500万年前,与动物的陆地化相吻合.
肠球菌的物种化与宿主多样化和重大灭绝事件并行.
选择了适应陆地生命的方法,比如在干旱和饥饿中生存.

结论:

能够在医院中壮成长的特征是在它们古老的陆地起源期间预先选择的.
这种进化历史解释了它们作为现代医院病原体的成功.

关键词:

肠球菌古生态时期抗生素耐药性开始的早期生活在医院获得的感染原产地种类化在地化

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