在体内呈现新奇与熟悉
Daisuke Hattori1, Yoshinori Aso2, Kurtis J Swartz1
1The Mortimer B. Zuckerman Mind Brain Behavior Institute, Department of Neuroscience, Columbia University, New York, NY 10032, USA.
Cell
|May 16, 2017
概括
果对新闻产生警觉反应, 由于多巴胺驱动的神经活动的变化,这种反应随着熟悉性而减弱.
科学领域:
- 神经科学
- 动物的行为
- 嗅觉系统研究
背景情况:
- 动物对不熟悉的感官输入有反应.
- 嗅觉系统可以处理气味信息.
- 青虫 (Drosophila melanogaster) 作为研究神经回路的模型生物.
研究的目的:
- 研究Drosophila嗅觉系统中新奇性和熟悉性的神经基础.
- 了解特定神经通路在对气味的行为反应中的作用.
- 阐明嗅觉学习和记忆的机制.
主要方法:
- 在Drosophila的电生理记录.
- 对嗅觉刺激的反应进行行为测试.
- 通过对神经回路进行光遗传操纵.
- 特定的神经元的遗传沉默.
主要成果:
- 新闻气味会激活体区内的特定输出神经元 (MBON).
- 在MBON中神经活动随着重复的气味暴露而迅速下降 (熟悉).
- 在这种神经活动过渡中,多巴胺能神经元活动至关重要.
- 激活α'3MBONs会引起警报反应,而沉默它们会消除警报反应.
结论:
- 的α'3体区对于处理新奇和熟悉的东西至关重要.
- 基尼恩细胞-MBONα'3突触中的多巴胺介导突触可塑性是嗅觉学习的基础.
- 这种回路在对新鲜和熟悉的嗅觉刺激的行为反应中起着因果作用.
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