慢性阻塞性肺部疾病
1LungenClinic Grosshansdorf, Airway Research Centre North, German Centre for Lung Research, Grosshansdorf, Germany; Department of Medicine, Christian Albrechts University Kiel, Kiel, Germany.
Lancet (London, England)
|May 18, 2017
概括
慢性阻塞性肺病 (COPD) 仍然是全球主要的健康问题,每年造成300多万人死亡. 在治疗方面取得的进展有限,这突显出需要更好地了解和全球努力减少烟草使用和环境暴露.
科学领域:
- 肺部医学
- 公共卫生
- 流行病学
背景情况:
- 慢性阻塞性肺病 (COPD) 是导致死亡的主要原因,全球每年有300多万人死亡.
- 目前的治疗主要是控制症状和预防恶化,对疾病进展或生存的影响有限.
- 在了解COPD发展背后的复杂机制方面存在重大差距.
研究的目的:
- 强调迫切需要更深入地了解COPD的发病过程.
- 突出减少全球COPD负担的重要策略.
- 倡导全面的公共卫生和政策干预.
主要方法:
- 关于COPD机制,治疗和预防的当前文献的审查.
- 对全球COPD死亡率和发病率数据的分析.
- 对吸烟,环境暴露和生物质燃料使用对COPD的影响的评估.
主要成果:
- 尽管治疗方面取得了进展,但COPD的进展和死亡率基本上没有受到影响.
- 戒烟,身体活动和并发症管理对于减少COPD的影响至关重要.
- 全球政治和经济行动对于制烟草使用和环境风险至关重要.
结论:
- 了解COPD复杂的机制对于开发有效的干预措施至关重要.
- 需要综合战略,包括戒烟,环境监管和替代燃料来源.
- 如果没有全球协同努力解决COPD的根本原因,它将继续成为医疗保健的重大挑战.
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