哺乳动物肠道神经系统的取决于血统的空间和功能组织
Reena Lasrado1, Werend Boesmans1,2, Jens Kleinjung1
1The Francis Crick Institute, 1 Midland Road, London NW1 1AT, UK.
概括
肠道神经系统 (ENS) 是由神经的祖先建立的重叠的克隆单元. 这种关键的肠道神经系统的组织和功能.
科学领域:
- 神经科学
- 发育生物学
- 胃肠病学
背景情况:
- 肠道神经系统 (ENS) 调节消化功能和肠道平衡.
- 了解肠神经系统的细胞起源和组织对于理解它的作用至关重要.
研究的目的:
- 研究小鼠内脏神经系统的克隆组成和空间组织.
- 确定ENS原生细胞发育和神经性承诺的分子调节者.
主要方法:
- 单细胞转录组学
- 突变性分析
- 在体内追踪神经衍生的祖先
主要成果:
- 鼠标ENS神经质网络被组织成由迁移后祖先衍生的重叠的克隆单元.
- 肠神经元的空间配置受到与无关细胞的相互作用,殖民模式和肠道扩张的影响.
- 确定了ENS原始体的动态分子状态,而RET则成为神经性承诺的关键调节者.
- 结核相关的肠神经元显示同步活动.
结论:
- 血统关系对于外周神经系统,特别是内脏系统的结构性组织至关重要.
- 这项研究揭示了克隆发育和细胞相互作用如何塑造肠道神经系统的复杂网络.
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