作为生物水的ATP
Avinash Patel1, Liliana Malinovska1, Shambaditya Saha1
1Max Planck Institute of Molecular Cell Biology and Genetics, 01307 Dresden, Germany.
概括
腺三酸盐 (ATP) 作为一种生物水,在高细胞度下防止和溶解蛋白质聚合物. 这种特性有助于维持蛋白质的溶解性,补充其作为能源的作用.
科学领域:
- 生物化学
- 分子生物学
- 化学生物学
背景情况:
- 热物是低合作性分子,在分子度下在水溶液中溶解疏水化合物.
- 经典的表面活性剂在聚合行为和度依赖性方面与热剂不同.
- 腺三酸盐 (ATP) 主要被称为细胞的能量货币,通常在微分子度中发现代谢反应.
研究的目的:
- 调查腺三酸盐 (ATP) 是否表现出热性质.
- 确定ATP是否可以影响蛋白质的可溶性和聚合状态.
- 探索ATP在维持细胞内蛋白质平衡中的潜在作用.
主要方法:
- 评估ATP在特定条件下防止新蛋白聚合的能力.
- 评估了ATP溶解预先形成的蛋白质聚合物的能力.
- 测量ATP度与其观察到的水热效应相关.
主要成果:
- 通过防止蛋白质聚合物的形成,腺三酸盐 (ATP) 显示出热特性.
- 在溶解现有的蛋白质聚合物方面,ATP也有效.
- 这些水热效应在ATP的生理毫米度 (5-10mM) 时被观察到.
结论:
- 氨酸三酸 (ATP) 除了作为能量来源之外,还作为一种生物水.
- 在毫米度下,ATP的水热性质可能有助于维持细胞中的蛋白质溶解性.
- 这一发现为ATP的高细胞内度提供了潜在的解释.
相关概念视频
Hydrolysis of ATP
82.5K
The bonds of adenosine triphosphate (ATP) can be broken through the addition of water, releasing one or two phosphate groups in an exergonic process called hydrolysis. This reaction liberates the energy in the bonds for use in the cell—for instance, to synthesize proteins from amino acids.
If one phosphate group is removed, a molecule of ADP—adenosine diphosphate—remains, along with inorganic phosphate. ADP can be further hydrolyzed to AMP—adenosine...
If one phosphate group is removed, a molecule of ADP—adenosine diphosphate—remains, along with inorganic phosphate. ADP can be further hydrolyzed to AMP—adenosine...
82.5K
ATP Driven Pumps I: An Overview
10.1K
ATP-driven pumps, also known as transport ATPases, are integral membrane proteins. They have binding sites for ATP located on the membrane's cytosolic side and the ion-conducting domain in the transmembrane region. These pumps use the free energy released from ATP hydrolysis to move the solutes across cell membranes against an electrochemical gradient.
There are four main types of ATP-driven pumps - P-type, V-type, F-type, and ABC transporter. All these pumps are of varying complexities and...
There are four main types of ATP-driven pumps - P-type, V-type, F-type, and ABC transporter. All these pumps are of varying complexities and...
10.1K
ATP Energy Storage and Release
14.8K
ATP is a highly unstable molecule. Unless quickly used to perform work, ATP spontaneously dissociates into ADP and inorganic phosphate (Pi), and the free energy released during this process is lost as heat. The energy released by ATP hydrolysis is used to perform work inside the cell and depends on a strategy called energy coupling. Cells couple the exergonic reaction of ATP hydrolysis with endergonic reactions, allowing them to proceed.
One example of energy coupling using ATP involves a...
One example of energy coupling using ATP involves a...
14.8K
ATP and Energy Production
2.3K
Adenosine triphosphate (ATP) is a critical molecule that functions as the main energy carrier in cells. Structurally, ATP consists of an adenosine molecule—comprising adenine and ribose—bonded to three phosphate groups. The high-energy bonds between these phosphate groups store significant amounts of potential energy. This energy is released during hydrolysis, wherein ATP is converted to adenosine diphosphate (ADP) or adenosine monophosphate (AMP), driving a variety of essential...
2.3K
ATP Synthase: Structure
16.4K
ATP synthase or ATPase is among the most conserved proteins found in bacteria, mammals, and plants. This enzyme can catalyze a forward reaction in response to the electrochemical gradient, producing ATP from ADP and inorganic phosphate. ATP synthase can also work in a reverse direction by hydrolyzing ATP and generating an electrochemical gradient. Different forms of ATP synthases have evolved special features to meet the specific demands of the cell. Based on their specific feature, ATP...
16.4K
Coupled Reactions
10.9K
Cellular processes such as building and breaking down complex molecules occur through stepwise chemical reactions. Some of these chemical reactions are spontaneous and release energy, whereas others require energy to proceed. Cells often couple the energy-releasing reaction with the energy-requiring one to carry out important cell functions.
Energy in adenosine triphosphate or ATP molecules is easily accessible to do work. ATP powers the majority of energy-requiring cellular reactions....
Energy in adenosine triphosphate or ATP molecules is easily accessible to do work. ATP powers the majority of energy-requiring cellular reactions....
10.9K


