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在小鼠胚胎中,一个胎盘生长因子被指蛋白ZFP568抑制

Peng Yang1, Yixuan Wang1,2, Don Hoang1

  • 1The Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892, USA.

Science (New York, N.Y.)
|May 20, 2017
PubMed
概括

指蛋白568 (ZFP568) 抑制了胎盘特异性的胰岛素类生长因子2 (IGF2) 转录. ZFP568的丢失导致IGF2删除的发育缺陷,揭示了ZFP568

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Genomic Imprinting and Inheritance02:30

Genomic Imprinting and Inheritance

Diploid organisms inherit genetic material through chromosomes from both parents. Copies of the same gene are known as alleles. In most cases, both alleles are simultaneously expressed and allow various cellular processes to function optimally. If one of the alleles is missing or mutated, the expression of the other allele can compensate; however, this is not true for all genes.
The expression of some genes depends on which parent passed the gene to the offspring, through a phenomenon known as...