自愈,自组合的β-叶片-多酸) 混合
David E Clarke1, E Thomas Pashuck1, Sergio Bertazzo1
1Department of Materials, ‡Institute of Biomedical Engineering, and §Department of Bioengineering, Imperial College London , Exhibition Road, London, SW7 2AZ, U.K.
Journal of the American Chemical Society
|May 20, 2017
概括
研究人员使用聚合物和自组合网络开发了自我愈合的混合. 这些生物材料具有可调节的机械性能,适用于组织工程和生物医学应用.
科学领域:
- 生物材料科学
- 聚合物化学
- 组织工程
背景情况:
- 自组装生物材料是可注射的,在现场形成,但通常缺乏用于生物应用的机械强度.
- 现有的材料在低压力下经常失去机械完整性,从而限制了它们的使用.
- 需要具有可调整机械性能和自我修复能力的先进生物材料.
研究的目的:
- 合成和描述具有增强机械性能和自我愈合能力的新型混合液.
- 调查β片移植密度与水凝机械性能之间的关系.
- 探索这些水凝作为组织工程和生物医学应用平台的潜力.
主要方法:
- 通过物理交叉链接聚 (γ-谷氨酸) 聚合物网络与移植的自组合β片来合成混合.
- 通过改变β片移植密度和度来调整机械性能.
- 使用光谱技术证实β片和探测二次结构的存在.
- 通过测量存储模块在机械故障后的恢复来评估自愈特性.
主要成果:
- 在10-200kPa范围内达到可调节的机械性能,与软组织相比.
- 具有显著的自我修复能力,由于重新组装β-sheet交叉连接而导致的故障后,水凝可以恢复存储模块.
- 通过光谱分析验证了混合水凝中β-片次要结构的存在.
- 确认水凝形成需要少于15%的功能化,允许进一步修改.
结论:
- 开发的自我愈合的聚合物-β片混合液具有适合软组织的可调性机械性能.
- 该β片交联机制提供了卓越的自我修复能力,在损坏后恢复机械完整性.
- 这些混合水凝为先进的组织工程支架和各种生物医学应用提供了有前途的平台.
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