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U6 snRNA m6 A甲基转移酶 METTL16 调节SAM合成酶的内保留

Kathryn E Pendleton1, Beibei Chen2, Kuanqing Liu3

  • 1Department of Microbiology, UT Southwestern Medical Center, Dallas, TX 75390, USA.

Cell
|May 20, 2017
PubMed
概括

甲基转移酶METTL16通过控制替代拼接来调节SAM合成酶 (MAT2A) 的表达. 这种机制有助于维持细胞S-adenosylmethionine (SAM) 稳态,而METTL16也会甲基化U6 snRNA.

关键词:
内部保留其他:其他类型N6-甲基氨酸 (m(6) A甲基化RNAS-adenosylmethionine (SAM) 的使用情况SAM的代谢过程U6 的 snRNA替代拼接甲氨酸

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