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淋巴内皮S1P促进了原始T细胞的线粒体功能和生存
Alejandra Mendoza1, Victoria Fang1, Cynthia Chen1
1Skirball Institute of Biomolecular Medicine, New York University School of Medicine, New York, New York 10016, USA.
Nature
|May 25, 2017
概括
斯芬戈辛-1-酸盐 (S1P) 对原始T细胞的生存和循环至关重要. 这项研究显示S1P信号维持T细胞线粒体,支持它们的长期存活和迁移.
科学领域:
- 免疫学
- 细胞生物学
- 分子生物学
背景情况:
- 单纯的T细胞对于适应性免疫是必不可少的,
- 随着年龄的增长,T细胞的产生会下降,因此需要长寿的T细胞.
- 在不断迁移期间支持原始T细胞存活的机制尚未完全理解.
研究的目的:
- 调查基酸盐 (S1P) 在原始T细胞存活和循环中的作用.
- 阐明参与T细胞平衡的S1P的细胞来源和信号通路.
- 探索针对T细胞相关疾病的S1P信号的治疗含义.
主要方法:
- 使用转基因小鼠模型研究T细胞贩卖和生存.
- 研究了S1P载体SPNS2在淋巴内皮细胞中的功能.
- 使用遗传方法分析了S1P受体S1P1在T细胞上的作用.
主要成果:
- 淋巴内皮细胞通过SPNS2分泌S1P,支持T细胞的存活.
- 通过S1P1在T细胞上传递S1P信号对于它们的生存至关重要,独立于迁移指导.
- S1P信号维持了原始T细胞中的线粒体含量,推动了它们的迁移.
结论:
- 除了在血液循环中的作用外,S1P也是原始T细胞的重要生存因子.
- 针对S1P信号通路可以提供一种双重的治疗策略,用于抑制T细胞贩运和增强细胞存活率.
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