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心血管功能和大脑的磁共振成像:痴呆是心血管驱动的疾病吗?
Albert de Roos1, Jeroen van der Grond2, Gary Mitchell2
1From Leiden University Medical Center, Department of Radiology, The Netherlands (A.d.R., J.v.d.G., J.W.); and Cardiovascular Engineering, Inc, Norwood, MA (G.M.). a.de_roos@lumc.nl.
Circulation
|June 1, 2017
概括
大动脉硬化常见于衰老和高血压, 损害大脑的血液流动, 可能导致认知衰退和痴呆. 通过MRI早期检测可能为这种心血管-大脑联系提供预防策略.
科学领域:
- 心血管医学
- 神经学
- 医学成像
背景情况:
- 靠近主动脉调节大脑的血液流动和脉动.
- 大动脉硬化与衰老和高血压有关, 负面影响大脑和心脏健康.
- 这可能导致脑小血管疾病,心力衰竭,认知衰退和血管痴呆.
研究的目的:
- 探索大动脉硬化与认知衰退之间的病理生理联系.
- 突出心血管疾病在痴呆中的作用.
- 确定预防和治疗的潜在目标.
主要方法:
- 使用磁共振成像 (MRI) 来评估近道主动脉和左心室功能.
- 测量主动脉脉冲波速率和延伸性.
- 使用MRI评估脑小血管疾病的早期和晚期症状 (微型出血,白质超强度).
- 探索先进的MRI技术用于临床前白质变化和大脑微血管脉动性.
主要成果:
- 大动脉硬化是脑损伤和心力衰竭的重要危险因素.
- 脑小血管疾病和心力衰竭与认知衰退和血管痴呆有关.
- 可以检测出有关认知障碍的动脉和大脑的功能和结构变化.
结论:
- 心血管疾病,特别是大动脉硬化, 是认知能力下降和痴呆的主要原因.
- 针对心血管-大脑轴的早期检测和干预至关重要.
- 先进的MRI技术显示出诊断临床前变化和指导预防策略的前景.
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