长期保存移植功能的策略
Thomas Wekerle1, Dorry Segev2, Robert Lechler3
1Department of Surgery, Section of Transplantation Immunology, Medical University of Vienna, Vienna, Austria.
Lancet (London, England)
|June 1, 2017
概括
移植的存活率在一年内超过95%,但长期的移植功能仍然具有挑战性. 分子诊断和免疫学的创新旨在改善长期的移植结果.
科学领域:
- 科和移植免疫学
- 计算生物学和精准医学
背景情况:
- 移植是治疗衰竭的标准方法,
- 虽然1年的移植存活率很高 (> 95%),但提高长期的移植功能是一个关键挑战.
- 捐赠者与接受者的匹配,移植物流和长期结果需要不断改进.
研究的目的:
- 为了回顾目前的移植进展.
- 突出改善捐赠者与接受者的匹配和长期移植保存的创新.
- 讨论移植医学的未来方向,包括耐受性诱导.
主要方法:
- 对目前的移植实践和新兴技术进行审查.
- 分子免疫学和计算生物学的整合,以加强匹配.
- 应用全局诊断和新型治疗策略.
主要成果:
- 先进的分子匹配 (HLA和非HLA) 提高了捐赠者-接受者的兼容性.
- 个性化诊断和治疗使得精确的治疗决定成为可能.
- 移植中心正在实施新兴创新,
结论:
- 分子免疫学和计算生物学方面的持续进步对于改善长期移植成功至关重要.
- 个性化医疗方法,包括全域诊断和新疗法,具有显著的潜力.
- 耐受性诱导是减少免疫抑制和增强移植寿命的未来目标.
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