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通过晚期内体酸3,4-双酸抑制mTORC1活动

Andrea L Marat1, Alexander Wallroth1, Wen-Ting Lo1

  • 1Leibniz-Forschungsinstitut für Molekulare Pharmakologie, Robert-Roessle-Strasse 10, 13125 Berlin, Germany.

Science (New York, N.Y.)
|June 3, 2017
PubMed
概括

由PI3KC2β产生的酸3,4-双酸[PI(3,4) P2] 作为拉巴胺复合物1 (mTORC1) 途径的新型抑制剂. 这一发现揭示了在营养缺乏期间控制细胞生长的新机制.

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