通过调节基底和神经性疼痛基因,miR-183集群可测量机械疼痛敏感性
Changgeng Peng1, Lili Li1, Ming-Dong Zhang2
1Department of Medical Biochemistry and Biophysics, Division of Molecular Neurobiology, Karolinska Institutet, 17177 Stockholm, Sweden.
Science (New York, N.Y.)
|June 3, 2017
概括
一个单一的微RNA集群可以调节正常疼痛和慢性神经性疼痛. 这种微RNA控制了参与疼痛的关键基因,
科学领域:
- 神经科学
- 分子生物学
- 疼痛研究
背景情况:
- 这是一种防止组织损伤的保护机制,但可能导致慢性疼痛.
- 保护性痛感和慢性疼痛的基本原则尚不清楚.
- 微RNA是基因表达的关键调节者,在各种生理过程中发挥作用.
研究的目的:
- 研究微RNA-183 (miR-183) 集群在调节基底机械敏感性和神经病痛方面的作用.
- 确定miR-183控制疼痛通路的分子机制.
- 探索针对miR-183治疗疼痛的治疗潜力.
主要方法:
- 使用小鼠模型研究基底机械敏感性和神经病痛.
- 研究了miR-183集群对基因表达的调节作用.
- 研究了电压通道子单元 (α2δ-1和α2δ-2) 和TrkB+轻触机械受体的参与.
主要成果:
- 在神经性疼痛中,miR-183集群控制了80%以上的基因.
- 该集群通过调节α2δ-1和α2δ-2子单元来调节基底机械灵敏度和机械力.
- 神经性疼痛涉及轻触机械受体,而这种疼痛被 gabapentin 逆转.
结论:
- 一个单一的微RNA集群,miR-183,在缩小急性机械敏感性和抑制神经病痛方面发挥着关键作用.
- miR-183通过向恶性受体和机械受体中的辅助电压通道子单元来调节疼痛.
- 向miR-183或其下游效应器是治疗慢性疼痛的潜在策略.
相关概念视频
01:25Analgesia and Pain Management
2.4K
Pain is critical to various clinical pathologies, provoking an urgent need for effective management. Pain, whether acute or chronic, is a complex neurochemical process. Its alleviation depends on the type, with nonopioid analgesics effective for mild to moderate pain, such as musculoskeletal or inflammatory pain, while neuropathic pain responds best to anticonvulsants, tricyclic antidepressants, or serotonin/norepinephrine reuptake inhibitors. For severe acute or chronic pain, opioids may be...
2.4K
01:44Nociception
33.5K
Nociception—the ability to feel pain—is essential for an organism’s survival and overall well-being. Noxious stimuli such as piercing pain from a sharp object, heat from an open flame, or contact with corrosive chemicals are first detected by sensory receptors, called nociceptors, located on nerve endings. Nociceptors express ion channels that convert noxious stimuli into electrical signals. When these signals reach the brain via sensory neurons, they are perceived as pain.
33.5K
01:20Pain
1.6K
Pain serves as a critical warning signal that alerts the body to potential or actual harm. When mechanical pressure on the skin is intense, such as from a sharp pinch, the sensation transitions from touch to pain. Similarly, extreme temperatures, like a hot pot handle, convert the sensation of heat into pain. Pain can also result from overstimulation of other senses, such as blinding light, loud noise, or the intense heat from habañero peppers. This ability to sense pain is essential for...
1.6K