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不匹配修复缺陷预测了固体瘤对PD-1封锁的反应

Dung T Le1,2,3, Jennifer N Durham1,2,3, Kellie N Smith1,3

  • 1Bloomberg-Kimmel Institute for Cancer Immunotherapy at Johns Hopkins, Baltimore, MD 21287, USA.

Science (New York, N.Y.)
|June 10, 2017
PubMed
概括

具有许多突变的不匹配修复缺陷癌症对编程死亡受体-1 (PD-1) 阻断的反应率很高. 这种免疫治疗方法在各种癌症中有效,为患者提供持久的益处.

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