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相关概念视频

Anatomy of the Eyeball01:20

Anatomy of the Eyeball

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The eye is a spherical, hollow structure composed of three tissue layers. The outer layer — the fibrous tunic, comprises the sclera — a white structure — and the cornea, which is transparent. The sclera encompasses some of the ocular surface, most of which is not visible. However, the 'white of the eye' is distinctively visible in humans compared to other species. The cornea, a clear covering at the front of the eye, enables light penetration. The eye's middle...
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Vision01:24

Vision

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Vision is the result of light being detected and transduced into neural signals by the retina of the eye. This information is then further analyzed and interpreted by the brain. First, light enters the front of the eye and is focused by the cornea and lens onto the retina—a thin sheet of neural tissue lining the back of the eye. Because of refraction through the convex lens of the eye, images are projected onto the retina upside-down and reversed.
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Neurogenesis and Regeneration of Nervous Tissue01:15

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In the CNS, neurogenesis, the birth of new neurons from stem cells, is limited to the hippocampus in adults. In other regions of the brain and spinal cord, neurogenesis is almost non-existent due to inhibitory influences from neuroglia, especially oligodendrocytes, and the absence of growth-stimulating cues. The myelin produced by oligodendrocytes in the CNS inhibits neuronal regeneration. Furthermore, astrocytes proliferate rapidly after neuronal damage, forming scar tissue that physically...
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The Retina01:32

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The retina is a layer of nervous tissue at the back of the eye that transduces light into neural signals. This process, called phototransduction, is carried out by rod and cone photoreceptor cells in the back of the retina.
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Photoreceptors and Visual Pathways01:22

Photoreceptors and Visual Pathways

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At the molecular level, visual signals trigger transformations in photopigment molecules, resulting in changes in the photoreceptor cell's membrane potential. The photon's energy level is denoted by its wavelength, with each specific wavelength of visible light associated with a distinct color. The spectral range of visible light, classified as electromagnetic radiation, spans from 380 to 720 nm. Electromagnetic radiation wavelengths exceeding 720 nm fall under the infrared category,...
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Visual System01:26

Visual System

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Light enters the eye through the cornea, a transparent, dome-shaped surface covering the surface of the eyeball that helps to direct and focus incoming light. This light is then channeled toward the pupil, an adjustable opening whose size is controlled by the iris. The iris, a pigmented muscle, regulates the amount of light entering the eye by contracting or dilating the pupil, thereby ensuring optimal light levels for clear vision.
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相关实验视频

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An Optic Nerve Crush Injury Murine Model to Study Retinal Ganglion Cell Survival
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从眼睛到大脑的视觉通路的再生

Bireswar Laha1, Ben K Stafford1, Andrew D Huberman2,3,4

  • 1Department of Neurobiology, Stanford University School of Medicine, Stanford, CA 94305, USA.

Science (New York, N.Y.)
|June 10, 2017
PubMed
概括

研究人员正在探索通过再生损坏的视网膜节细胞 (RGC) 恢复视力的方式. 有希望的策略包括重新激活生长程序,使用基因疗法,开发视网膜假肢来修复视力.

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科学领域:

  • 神经科学
  • 眼科 眼科
  • 复原医学

背景情况:

  • 人们非常依赖视力, 恢复视力成为一个关键目标.
  • 视网膜质细胞 (RGC) 对于向大脑传输视觉信息至关重要.
  • 由于RGC的再生能力有限,导致不可逆转的视力丧失.

研究的目的:

  • 审查目前关于光学系统再生和修复的研究.
  • 探索潜在的治疗策略,以恢复失明的病例.
  • 评估恢复人类视力的可行性.

主要方法:

  • 对RGC再生和光学系统修复的现有科学文献的审查.
  • 对研究RGC内在生长计划的分析.
  • 检查神经活动,移植,基因疗法和视网膜假肢的研究.

主要成果:

  • 可以在RGC中重新激活内在发育程序以促进再生.
  • 神经活动可以增强RGC的再生潜力.
  • 即使在成年人中,也可以恢复眼与大脑的功能.

结论:

  • 视觉系统的再生和修复是对抗失明的可行途径.
  • 基因疗法和视网膜假体等治疗方法有望恢复视力.
  • 在某些形式的失明中, 预计在不久的将来能恢复正常的视力.