编排定向分子运动:螺旋主体在棒状客体上的动力控制的超分子路径
Xiang Wang1, Barbara Wicher1, Yann Ferrand1
1CBMN Laboratory, University of Bordeaux, CNRS, IPB, Institut Européen de Chimie Biologie, 2 rue Escarpit 33607 Pessac, France.
Journal of the American Chemical Society
|June 14, 2017
概括
研究人员设计了自组装的芳香胺,为胺客制造双螺旋主体. 这些折叠复合体展示了受控的分子运动和复杂的超分子事件,为动态分子系统提供了洞察力.
科学领域:
- 超分子化学
- 有机化学
- 材料科学
背景情况:
- 芳香胺可以自组成复杂的结构.
- 设计具有可控制动态的宿主-客系统是超分子化学的一个关键挑战.
研究的目的:
- 设计和合成一个双螺旋主体,能够结合线性小碳酸盐客体.
- 研究螺旋主体内客串,滑动和解离的动力学.
- 证明foldaxanes在编程复杂的超分子事件中的潜力.
主要方法:
- 芳香胺主体和功能化胺客体的设计和合成.
- 使用核磁共振 (NMR) 和X射线晶体学对折叠素复合物形成的表征.
- 使用H NMR监测客串线程,滑动和解离动态的动态研究.
主要成果:
- 在橄胺宿主和橄酸宿主之间成功形成螺旋式伪复合体 (foldaxanes).
- 在宿主滑动过程中观察复杂的动态事件,包括中间结合和在间隔器上快速滑动.
- 演示动力障碍可以控制超分子轨迹,使分离-重组步骤的故意集成成为可能.
- 快速滑动过程 (小时) 和较慢的螺旋解回合事件 (天) 的区别.
结论:
- 福尔达克桑为研究和控制超分子系统中的分子运动提供了多功能平台.
- 单个步骤的动力学可以调整为设计超分子事件的复杂序列.
- 这项工作推进了动态分子架构和功能超分子材料的设计原则.
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