恒常电路在岛内皮层中选择性地进入食物提示反应
Yoav Livneh1, Rohan N Ramesh1,2, Christian R Burgess1
1Division of Endocrinology, Diabetes and Metabolism, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02215, USA.
Nature
|June 15, 2017
概括
饥饿状态会影响小鼠对食物的反应. 一个来自饥饿神经元的特定神经通路会覆盖腹信号,
科学领域:
- 神经科学
- 生理学
- 行为科学
背景情况:
- 身体需要,如饥饿,影响知觉和注意力.
- 这些过程的失调与成,肥胖和饮食障碍有关.
- 岛屿皮层参与处理动机相关的线索, 但底层的电路机制尚不清楚.
研究的目的:
- 根据生理状态,研究皮质下电路如何偏向对动机相关线索的皮质处理.
- 阐明参与饥饿驱动的岛屿皮层活动的神经通路.
主要方法:
- 开发了一种基于微镜的细胞成像技术,用于监测小鼠的岛内皮层神经元活动.
- 使用化学遗传学操纵的下丘脑阿古蒂相关 (AgRP) 神经元.
- 使用电路跟踪和特定路径操纵绘制神经路径.
主要成果:
- 岛上皮层神经元表现出食物偏差反应,在腹时减少.
- AgRP"饥饿神经元"的化学激活恢复了与内脏腹信号无关的类似饥饿的岛屿皮质反应.
- 从AgRP神经元到岛屿皮层通过腹腔体和桃体的新途径.
结论:
- 揭示了神经回路的基础, 如何生理状态, 特别是饥饿,
- 证明下丘脑饥饿信号可以直接调节岛屿皮层活动,
- 这一发现对理解成和肥胖等动机行为和疾病有意义.
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