在非洲瘤病患者的双盲研究中,对ivermectin和diethylcarbamazine进行了双盲研究,这些患者的眼睛受到了影响
Lancet (London, England)
|July 27, 1985
概括
单次口服剂量伊弗麦丁 (Ivermectin) 已被证明比二甲基碳氨酸 (DEC) 更有效治疗癌症. 这项研究发现,在减少微粒细胞和解决眼部症状方面,ivermectin在副作用较少的情况下优越.
科学领域:
- 医学寄生虫学 医学寄生虫学
- 热带医学 热带医学
- 临床药理学 临床药理学
背景情况:
- 由Onchocerca volvulus引起的皮瘤是可预防失明的重要原因之一.
- 目前的治疗方法,如二甲基碳氨酸 (DEC),在疗效和副作用方面存在局限性.
研究的目的:
- 为了比较ivermectin与DEC在治疗具有眼睛干扰的肉病的疗效和安全性.
- 评估ivermectin和DEC在皮肤和前腔中的微杀菌活性.
主要方法:
- 一个随机的,双盲的,安慰剂对照试验,涉及30名患有瘤瘤的男性患者.
- 患者在12个月内接受单次口服剂量 (12毫克) 艾弗梅克丁,每日DEC (总计1.3克) 或安慰剂.
- 定期进行眼科检查和皮肤和前腔中的微细菌计数.
主要成果:
- 艾弗迈克丁在6/7名患者中解决了点状角膜炎,而DEC没有改善.
- 在大多数ivermectin患者中,前腔微菌在六个月内消失了.
- 这两种药物都减少了皮肤微细菌,但ivermectin在12个月内保持了较低的水平 (9%的基线与DEC的45%相比).
- 与DEC相比,艾弗梅克丁的副作用较少且不那么严重.
结论:
- 单剂量艾弗麦丁是一种比DEC更有效的微杀药剂,用于瘤.
- 艾弗梅克丁在解决眼部表现和持续减少微细菌菌方面表现出卓越的疗效.
- 艾弗梅克丁在瘤病治疗中提供了更好的安全性.
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