隔天服用普雷尼松可降低发病率,并改善囊性纤维化患者的肺功能
Lancet (London, England)
|September 28, 1985
概括
替代日普雷尼松疗法显著改善了肺功能,并在四年内减少了患有囊性纤维化 (CF) 的儿童的住院治疗,没有副作用.
科学领域:
- 儿科 儿科 儿科
- 肺部病理学 肺部病理学
- 药理学 药理学是指药理学的学科.
背景情况:
- 囊性纤维化 (CF) 是一种影响多个器官,主要是肺部的遗传性疾病.
- 肺部疾病的进展和相关的发病率是儿童CF患者的重大问题.
- 优化治疗策略以减缓疾病进展至关重要.
研究的目的:
- 评估替代日普得尼松疗法在治疗CF儿童肺部疾病进展的有效性.
- 评估普得尼松对CF患者各种临床和生理参数的影响.
- 确定长期交替使用普得尼松在这个人群中的安全性.
主要方法:
- 进行了一项随机,双盲,安慰剂控制的试验.
- 参与者是小儿病 (1-12岁) 患者,在基线时患有轻度至中度的肺部疾病.
- 患者在四年内接受了交替日前尼松或安慰剂.
主要成果:
- 与安慰剂相比,接受普雷尼松治疗的患者在身高,体重,生命能力,FEV1,峰值流量,ESR和血清IgG方面显著改善.
- 与CF相关的肺部疾病的入院病例在普得尼松组 (9次入院) 与安慰剂组 (35次入院) 相比,在普得尼松组 (9次入院) 实质性较低.
- 在研究期间没有观察到任何显著的类固醇诱导的副作用.
结论:
- 替代日普得尼松疗法是改善临床结果和减少儿科CF患者肺部恶化的一种有效治疗方法.
- 该疗法表现出良好的安全性,在四年内没有明显的不良影响.
- 这种治疗方法为管理囊性纤维化肺部疾病进展提供了一个有希望的策略.
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