通过 ((II) 基金属基催化方式对酸酸酸酸的不对称的激进自行车化
Huiling Jiang1, Kai Lang2, Hongjian Lu1
1Department of Chemistry, University of South Florida , Tampa, Florida 33620, United States.
Journal of the American Chemical Society
|June 27, 2017
概括
(II) 催化剂能够有效地从基酸酸酸盐中合成奇拉双循环亚齐里丁. 这种金属化方法可以实现复杂的化环结构的高产量和选择性.
科学领域:
- 有机金属化学 有机金属化学
- 不对称的催化剂.
- 合成有机化学 合成有机化学
背景情况:
- 金属基催化提供了一个强大的策略,用于C-C和C-异原子键的形成.
- 奇拉尔亚齐里丁是药品和天然产品的有价值的合成中间体.
- 开发用于构建复杂的双循环系统的enantioselective方法仍然是一个重大挑战.
研究的目的:
- 调查基于 ((II) 的金属基催化剂对于激进循环反应的有用性.
- 开发一种高度选择性的方法,用于合成阿齐里丁/奥克萨索利丁融合的双循环结构.
- 确定一种有效的性催化剂,用于碳酸的分子内激素亚齐里迪纳化.
主要方法:
- 使用一个D2-对称的合性Cobalt(II) amidoporphyrin复合物 (3,5-Di(tBu) -QingPhyrin) 作为金属化催化剂.
- 采用基亚酸盐作为分子内激素亚化基质.
- 优化反应条件以实现高产量和立体选择性.
主要成果:
- 成功演示了II催化酸酸酸酸酸盐的基态循环.
- 实现了合成有用的性[3.1.0]-双循环亚齐里丁的高产形成.
- 在形成双循环产品时表现出优异的二选择性和反选择性.
结论:
- 以为基础的化催化是构建复杂性双循环亚齐里丁的有效方法.
- 奇拉式QingPhyrin催化剂能够实现高度立体选择性的分子内激素阿齐里迪纳.
- 这种方法提供了一条有价值的途径,以获得化双循环支架,富含酶体.
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