心炎作为隐性癌症的标志物和癌症死亡率的预后因素
Kirstine Kobberøe Søgaard1, Dóra Körmendiné Farkas2, Vera Ehrenstein2
1From Department of Clinical Epidemiology, Institute of Clinical Medicine, Aarhus University Hospital, Denmark (K.K.S., D.K.F., V.E., H.T.S.); Non-Communicable Diseases Epidemiology, London School of Hygiene and Tropical Medicine, United Kingdom (K.B.) Department of Cardiology, Aarhus University Hospital, Skejby, Denmark (H.E.B.); and Department of Health Research and Policy (Epidemiology), Stanford University, CA (H.T.S.). kks@clin.au.dk.
胸膜炎可能是隐藏癌症的信号,增加癌症风险和死亡率. 早期诊断心膜炎可能有助于检测隐藏的恶性瘤.
科学领域:
- 心脏病学
- 癌症学
- 流行病学
背景情况:
- 心炎是已知的恶性瘤并发症.
- 心膜炎作为隐性癌症的初始症状的作用及其对癌症存活率的影响尚不清楚.
研究的目的:
- 调查心膜炎和随后的癌症诊断之间的联系.
- 确定心膜炎是否可以预测癌症的存活率.
主要方法:
- 在丹麦,1994年至2013年间对13,759名被诊断患有急性心膜炎的患者进行了全国性队列研究.
- 以后的癌症诊断的后续行动,将癌症风险和发病率与一般人群进行比较.
- 使用卡普兰-梅尔和考克斯回归评估癌症存活率,与没有心膜炎的匹配队列进行比较.
主要成果:
- 1550名患者在经过心膜炎诊断后发展为癌症. 整体癌症标准化发生率为1. 5.
- 在心周炎的3个月内显著增加癌症风险 (SIR 12. 4),特别是肺癌,脏癌,膀癌和淋巴瘤.
- 癌症诊断后心周炎与死亡率增加有关 (3 个月 HR 1. 5, 1 年 HR 1. 3).
结论:
- 心炎是潜在的隐性癌症的标志物.
- 在癌症诊断后,心膜炎的诊断与预后较差和死亡率增加有关.
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