在瘤微环境中采用IFNγ依赖性组织免疫平衡
Christopher J Nirschl1, Mayte Suárez-Fariñas2, Benjamin Izar3
1Department of Dermatology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA.
Cell
|July 1, 2017
概括
免疫细胞共享一种由干扰素- (IFNγ) 诱导的同质化程序,这种程序被瘤所采用. 这项涉及细胞因子抑制剂-2 (SOCS2) 的计划限制了抗瘤免疫力,并影响了患者的生存率.
科学领域:
- 免疫学
- 癌症生物学
- 细胞平衡
背景情况:
- 免疫平衡平衡保护和自我耐受,影响自身免疫和瘤形成.
- 维持平衡的机制及其对瘤监测的影响在很大程度上是未知的.
研究的目的:
- 研究如何维持免疫平衡以及它如何影响瘤监测.
- 确定瘤微环境中免疫恒常的关键分子参与者和途径.
主要方法:
- 人类黑色素瘤样本的单细胞RNA测序 (RNA-seq).
- 免疫单核细胞的分析,包括单核细胞和树突细胞 (DCs).
- 干扰因子 (IFNγ) 刺激测定和体内研究.
主要成果:
- 在免疫单核细胞中,IFNγ诱导了保存的恒常计划.
- 这种依赖IFNγ的程序在包括黑色素瘤在内的原发性人体瘤中得到了丰富,并且与生存相关.
- 抑制细胞因子-2 (SOCS2) 是该程序的关键转录,限制了抗瘤免疫力和T细胞启动.
结论:
- 免疫恒常机制被瘤微环境所采用.
- 由SOCS2介导的IFNγ诱导的平稳计划在限制抗瘤免疫力方面发挥着关键作用.
- 这些发现将免疫平衡与瘤免疫逃生联系起来,并确定潜在的治疗点.
更多相关视频
相关概念视频
02:17The Tumor Microenvironment
8.0K
Every normal cell or tissue is embedded in a complex local environment called stroma, consisting of different cell types, a basal membrane, and blood vessels. As normal cells mutate and develop into cancer cells, their local environment also changes to allow cancer progression. The tumor microenvironment (TME) consists of a complex cellular matrix of stromal cells and the developing tumor. The cross-talk between cancer cells and surrounding stromal cells is critical to disrupt normal tissue...
8.0K
01:27Tumor Immunotherapy
2.1K
Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
2.1K
01:28Inflammatory Response
17.5K
An inflammatory response is a localized, nonspecific immune reaction that occurs when a tissue is injured. It is characterized by redness, swelling, heat, and pain, which are commonly called the cardinal signs and symptoms of inflammation. Inflammation can sometimes result in a loss of function.
Inflammation can be triggered by various stimuli, such as impact, abrasion, chemical irritation, infections, and extreme hot or cold temperatures. These can damage cells and connective tissue fibers,...
Inflammation can be triggered by various stimuli, such as impact, abrasion, chemical irritation, infections, and extreme hot or cold temperatures. These can damage cells and connective tissue fibers,...
17.5K
01:28Cells of the Innate Immune Response
9.8K
The innate immune response is an immediate and non-specific response against pathogens, acting swiftly to prevent the spread of infections. The primary cells involved in this response are phagocytes and natural killer (NK) cells.
Phagocytes
Phagocytes police the peripheral tissues by removing cellular debris and responding to the invasion of foreign substances or pathogens. Many phagocytes attack and remove microorganisms even before lymphocytes detect them. The human body has two general...
Phagocytes
Phagocytes police the peripheral tissues by removing cellular debris and responding to the invasion of foreign substances or pathogens. Many phagocytes attack and remove microorganisms even before lymphocytes detect them. The human body has two general...
9.8K
02:26NF-κB-dependent Signaling Pathway
10.1K
The transcription factor NF-κB was discovered in 1986 in the lab of Nobel laureate Professor David Baltimore, for its interaction with the immunoglobulin light chain enhancer in B-cells. After more than three decades of study, it is now evident that NF-κB regulates the expression of over 100 genes. Most of these genes play an essential role in the innate and adaptive immune responses as well as the inflammatory responses of animals.
NF-κB-dependent Signaling Mechanism
The...
NF-κB-dependent Signaling Mechanism
The...
10.1K
01:40Cell-mediated Immune Responses
85.0K
Overview
85.0K