口前肠道有助于非远鱼的面部结构
Martin Minarik1, Jan Stundl1,2, Peter Fabian1
1Department of Zoology, Charles University, Prague, Czech Republic.
Nature
|July 6, 2017
概括
脊椎动物的口腔发育不均. 鱼类胚胎的口前肠道 (POGD) 起源于前肠,形成面部结构并挑战传统的发育模型.
科学领域:
- 发育生物学
- 进化生物学
- 比较解剖学
背景情况:
- 脊椎动物的口腔发育传统上被视为均,涉及口腔形成的外皮发育.
- 外皮和内皮通常分别是发育中的口腔的外表面和内表面.
研究的目的:
- 调查现存的非远鱼的早期口腔发育.
- 识别胃部发育之前的新发育过程.
- 探索面结构的进化起源.
主要方法:
- 微型计算机断层扫描 (微型CT) 对比希尔,鱼和加尔胚胎的成像.
- 在体内进行血统追踪实验以追踪内皮细胞命运.
- 对POGD形态和基因表达的比较分析.
主要成果:
- 在非teleost鱼类胚胎中,突出的口前肠道分流器 (POGD) 从前肠形成之前形成.
- POGD有助于幼虫的面部结构,包括鱼的牙,嘴唇和.
- POGD 在bichir和gar中形成了头骨粘合器官,这表明它在鱼中起着祖先的作用.
结论:
- 发现POGD挑战了脊椎动物口均发育的范式.
- 在脊椎动物中首次证明了外面结构的内皮起源.
- POGD 代表了一种保存的发育模块,其起源深处,可能与早期的带状细胞进化有关.
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