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A Nonviral Approach to Generate Transient Chimeric Antigen Receptor T Cells Using mRNA for Cancer Immunotherapy
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个性化RNA突变体疫苗可以动员针对癌症的多特异性治疗免疫力

Ugur Sahin1,2,3, Evelyna Derhovanessian1, Matthias Miller1

  • 1Biopharmaceutical New Technologies (BioNTech) Corporation, An der Goldgrube 12, 55131 Mainz, Germany.

Nature
|July 6, 2017
PubMed
概括

针对癌症突变的个性化RNA疫苗成功激活了黑色素瘤患者的T细胞. 这种个性化免疫治疗方法显著减少了转移性事件,并改善了无进展的存活率,证明了癌症治疗的新途径.

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